Computed Tomography Versus Exercise Testing in Suspected Coronary Artery Disease (CRESCENT)

This study has been terminated.
(Insufficient funds)
Information provided by (Responsible Party):
Koen Nieman, Erasmus Medical Center Identifier:
First received: June 27, 2011
Last updated: November 11, 2014
Last verified: November 2014
Direct non-invasive coronary imaging by computed tomography (CT) has the potential to improve the workup of patients with stable chest pain complaints. The objective of the study is to compare in a randomized fashion the effectiveness and efficiency of a CT angiographic driven workup of suspected coronary artery disease in comparison to the standard workup using stress testing.

Condition Intervention
Angina Pectoris
Chest Pain
Other: Cardiac CT
Other: Standard care

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Diagnostic
Official Title: Computed Tomography Versus Exercise Testing in Suspected Coronary Artery Disease

Resource links provided by NLM:

Further study details as provided by Erasmus Medical Center:

Primary Outcome Measures:
  • Chest pain [ Time Frame: 1 year ] [ Designated as safety issue: No ]
    Reduction of chest pain symptoms by standardized questionnaire, at one year follow-up

  • Class IA Revascularizations [ Time Frame: 1 year ] [ Designated as safety issue: No ]
    Number of revascularizations with an ESC class 1A indication

Secondary Outcome Measures:
  • Overall medical expenses [ Time Frame: 1 year ] [ Designated as safety issue: No ]
    Overall medical expenses

  • Cost-effectiveness [ Time Frame: 1 year ] [ Designated as safety issue: No ]
    Cost-effectiveness analysis based on the overall quality of life and medical expenses at one year.

  • Radiation dose [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]
    Cumulative radiation exposure at one year

  • Major adverse cardiovascular events [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]

    Composite endpoint of adverse cardiovascular events, including:

    All-cause mortality Non-fatal myocardial infarction Unstable angina requiring hospital admission Late revascularization procedures (>6 months after initial evaluation)

  • Quality of life [ Time Frame: 1 year ] [ Designated as safety issue: No ]
    Change of quality of life at 1 year

Enrollment: 350
Study Start Date: July 2011
Study Completion Date: August 2014
Primary Completion Date: August 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Cardiac CT
Cardiac CT (CT calcium and/or CT angiography), followed by stress testing, invasive angiography or neither depending on the CT scan result
Other: Cardiac CT
Cardiac CT: calcium scan and CT coronary angiography
Standard care
Standard diagnostic management, including stress testing and/or invasive angiography
Other: Standard care
Standard care according to international guidelines


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Men and women aged >18 years.
  • Stable symptoms of chest pain or dyspnea potentially caused by obstructive CAD.

Exclusion Criteria:

  • A history of surgical or percutaneous coronary revascularization
  • Non-revascularized angiographic obstructive coronary artery disease (>50% diameter reduction).
  • Normal invasive coronary angiography or stress imaging less than 1 years ago.
  • Inability or unwillingness to provide informed consent.
  Contacts and Locations
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Please refer to this study by its identifier: NCT01393028

MC Haaglanden
Leidschendam, Netherlands
Erasmus MC
Rotterdam, Netherlands
Rotterdam, Netherlands
Rotterdam, Netherlands
Sponsors and Collaborators
Erasmus Medical Center
  More Information

Responsible Party: Koen Nieman, Dr K Nieman, Erasmus Medical Center Identifier: NCT01393028     History of Changes
Other Study ID Numbers: CRESCENT-11 
Study First Received: June 27, 2011
Last Updated: November 11, 2014
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by Erasmus Medical Center:
coronary artery disease
angina pectoris
Stable chest pain complaints

Additional relevant MeSH terms:
Angina Pectoris
Chest Pain
Coronary Artery Disease
Coronary Disease
Myocardial Ischemia
Arterial Occlusive Diseases
Cardiovascular Diseases
Heart Diseases
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Vascular Diseases processed this record on May 30, 2016