Magnetic Resonance Imaging (MRI) of Appendicitis in Children

This study has been completed.
Information provided by (Responsible Party):
Pranav Vyas, Children's Research Institute Identifier:
First received: July 25, 2008
Last updated: November 14, 2014
Last verified: November 2014
Study to find out if MRI can diagnose appendicitis in children as well as or better than CT scan and/or ultrasound scan performed at the same time. No additional contrast material or sedation will be used to perform the MRI.

Condition Intervention
Device: MRI of the abdomen

Study Type: Interventional
Study Design: Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Diagnostic
Official Title: Magnetic Resonance Evaluation of Appendicitis in Children Aged 8-18

Resource links provided by NLM:

Further study details as provided by Children's Research Institute:

Primary Outcome Measures:
  • Diagnostic Sensitivity/Specificity and Accuracy of Appendiceal MRI Comparedsurgical Findings or Clinical Follow-up [ Time Frame: during diagnostic procedure ] [ Designated as safety issue: No ]
    Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV)

Enrollment: 21
Study Start Date: August 2008
Study Completion Date: April 2010
Primary Completion Date: April 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Only one arm
All patients enrolled will receive an MRI of the abdomen with detailed views of the appendix
Device: MRI of the abdomen
Multiple MRI pulse sequences of the abdomen


Ages Eligible for Study:   8 Years to 18 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Age 8-18 years, referred from emergency department for suspected appendicitis and receiving either CT scan or ultrasound of the abdomen for diagnosis

Exclusion Criteria:

  • Failure to pass MRI metal screening. Claustrophobia or need for sedation due to inability to hold still.
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Please refer to this study by its identifier: NCT00723788

United States, District of Columbia
Children's National Medical Center
Washington, District of Columbia, United States, 20010
Sponsors and Collaborators
Children's Research Institute
Principal Investigator: Pranav K Vyas, MD Children's Research Institute
  More Information

Responsible Party: Pranav Vyas, Assistant Professor of Radiology and Pediatrics, Children's Research Institute Identifier: NCT00723788     History of Changes
Other Study ID Numbers: CNMC4024 
Study First Received: July 25, 2008
Results First Received: November 5, 2014
Last Updated: November 14, 2014
Health Authority: United States: Institutional Review Board

Keywords provided by Children's Research Institute:
Magnetic Resonance Imaging

Additional relevant MeSH terms:
Cecal Diseases
Digestive System Diseases
Gastrointestinal Diseases
Intestinal Diseases
Intraabdominal Infections processed this record on May 24, 2016