Intensive Strength Training in Children With Cerebral Palsy - Effect on Hand Function

This study has been completed.
Norwegian University of Science and Technology
Information provided by (Responsible Party):
St. Olavs Hospital Identifier:
First received: April 27, 2007
Last updated: April 15, 2016
Last verified: April 2016
The objective of this study is to gain more knowledge about the association between muscle weakness, spasticity and motor control in children with cerebral palsy, and its relationship to hand function.

Condition Intervention Phase
Cerebral Palsy
Drug: Botulinum Toxin A
Behavioral: Resistance training
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Intensive Strength Training in Children With Cerebral Palsy - Effect on Hand Function

Resource links provided by NLM:

Further study details as provided by St. Olavs Hospital:

Enrollment: 10
Study Start Date: September 2006
Study Completion Date: March 2008
Primary Completion Date: October 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: BoNT A
Botulinum toxin A injections in muscles of the arm (biceps brachii and brachialis)
Drug: Botulinum Toxin A
Other Names:
  • Botox
  • BoNT A
Experimental: Resistance training
8 weeks resistance training
Drug: Botulinum Toxin A
Other Names:
  • Botox
  • BoNT A
Behavioral: Resistance training
Other Name: Strength training


Ages Eligible for Study:   10 Years to 17 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Diagnosed spastic hemiplegic or diplegic cerebral palsy, reduced handfunction.
  • Indication for treatment with Botulinum Toxin A
  • Score 3 on House Classification of Upper-Extremity Functional Use
  • Score 3 or better on Manual Ability Classification System

Exclusion Criteria:

  • surgery within the last two years
  • Treatment with Botulinum Toxin within the last six months
  Contacts and Locations
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Please refer to this study by its identifier: NCT00467207

St. Olavs Hospital
Trondheim, Norway, 7004
Sponsors and Collaborators
St. Olavs Hospital
Norwegian University of Science and Technology
Study Chair: Torarin I Lamvik, md St. Olavs Hospital
Principal Investigator: Karin Roeleveld, phd Norwegian University of Science and Technology
  More Information

Responsible Party: St. Olavs Hospital Identifier: NCT00467207     History of Changes
Other Study ID Numbers: 06/1553 
Study First Received: April 27, 2007
Last Updated: April 15, 2016
Health Authority: Norway: Norwegian Social Science Data Services

Additional relevant MeSH terms:
Cerebral Palsy
Brain Damage, Chronic
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Botulinum Toxins
Botulinum Toxins, Type A
Acetylcholine Release Inhibitors
Cholinergic Agents
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Neuromuscular Agents
Neurotransmitter Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs processed this record on May 22, 2016