SOURCE XT REGISTRY

This study is currently recruiting participants.
Verified September 2012 by Edwards Lifesciences
Sponsor:
Information provided by (Responsible Party):
Edwards Lifesciences
ClinicalTrials.gov Identifier:
NCT01238497
First received: October 26, 2010
Last updated: September 11, 2012
Last verified: September 2012
  Purpose

This registry is to expand upon existing data sets, to identify patient characteristics and indicators related to complications and clinical benefits for patients with symptomatic severe calcific degenerative aortic stenosis that are undergoing treatment with the commercially available Edwards SAPIEN XT™ Valve, and delivery devices.


Condition Intervention
Severe Aortic Stenosis
Device: Aortic Valve Replacement

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: SAPIEN XT™ Aortic Bioprosthesis Multi-region Outcome Registry

Resource links provided by NLM:


Further study details as provided by Edwards Lifesciences:

Primary Outcome Measures:
  • Assess and track causality and sequelae of major adverse events [ Time Frame: 30 days ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • Effectiveness: observe trends in patient characteristics and outcomes over time [ Time Frame: One year ] [ Designated as safety issue: No ]

Estimated Enrollment: 2000
Study Start Date: September 2010
Estimated Study Completion Date: December 2017
Estimated Primary Completion Date: December 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Other Device: Aortic Valve Replacement
Implantation of aortic transcatheter heart valves via the percutaneous transfemoral and the transapical approach

Detailed Description:

Consecutive patient data should be collected at discharge, 30 days and 12 months post-implant. Subsets of patients may undergo additional follow-up.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients with symptomatic aortic stenosis

Criteria

Inclusion Criteria:

  • The SAPIEN XT™ THV is indicated for use in patients with symptomatic aortic stenosis requiring TAVI who have a high risk for operative mortality, or are "non-operable"

Exclusion Criteria:

  • Non-valvular or congenital aortic stenosis
  • Pre-existing prosthetic heart valve in the Aortic position or a non-calcified aortic valve
  • Severe (>3+) mitral insufficiency or aortic regurgitation > 3+
  • Active bacterial endocarditis or other active infections
  • Severe ventricular dysfunction with ejection fraction < 20%
  • Coronary artery disease-related unstable angina
  • Inability to tolerate anticoagulation / antiplatelet therapy
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01238497

Contacts
Contact: Emilie Ferrandini +41 22 787 4483 emilie_ferrandini@edwards.com

  Hide Study Locations
Locations
Austria
Universitatsklinik Innsbruck Active, not recruiting
Innsbruck, Austria, 6020
Medical University Vienna Recruiting
Vienna, Austria, 1090
Contact: Wilfried Wisser, MD     +43 1 40400 5620     wilfried.wisser@meduniwien.ac.at    
Principal Investigator: Wilfried Wisser, MD            
Belgium
Onze Lieve Vrouw Ziekenhuis Active, not recruiting
Aalst, Belgium, 9300
Clinique St Luc Active, not recruiting
Bouge, Belgium, 5004
Cliniques Universitaires Saint Luc Active, not recruiting
Brussels, Belgium, 1200
Universitaire Ziekenhuizen Leuven Active, not recruiting
Leuven, Belgium, 3000
Canada, Alberta
Foothills Medical Centre Not yet recruiting
Calgary, Alberta, Canada, T2N 2T9
Contact: Faisal Al Qoofi, MD     403-944-1192     falqoofi@gmail.com    
Contact: Deb Lundgren, RN     403-944-1192     Deb.Lundberg@albertahealthservices.ca    
Principal Investigator: Faisal Al Qoofi, MD            
University of Alberta Hospital Not yet recruiting
Edmonton, Alberta, Canada, T6G 2B7
Contact: Rob Welsh, MD     780-407-3613     Robert.Welsh@albertahealthservices.ca    
Contact: Suzanne Welsh, RN     780-407-3572     Suzanne.Welsh@albertahealthservices.ca    
Principal Investigator: Rob Welsh, MD            
Canada, British Columbia
St. Paul's Hospital Not yet recruiting
Vancouver, British Columbia, Canada, V6Z 1Y6
Contact: John Webb, MD     604-806-8902     webb@providencehealth.bc.ca    
Contact: Elizabeth Grieve, RN     604-806-8804     egrieve@providencehealth.bc.ca    
Principal Investigator: John Webb, MD            
Canada, New Brunswick
St. John Regional Hospital Not yet recruiting
Saint John, New Brunswick, Canada, E2L 4L2
Contact: Mark Pelletier, MD     506-648-6102     Marc.Pelletier@HorizonNB.ca    
Contact: Carole Dube, RN     506-648-6000     carole.dube@horizonnb.ca    
Principal Investigator: Mark Pelletier, MD            
Canada, Ontario
Hamilton Health Services Not yet recruiting
Hamilton, Ontario, Canada, L8L 2X2
Contact: Madhu Natarajan, MD     905-527-2337     natarajm@ccc.mcmaster.ca    
Contact: Corinne Tartalgia, RN     905-577-1417     reynocor@hhsc.careynocor@hhsc.ca    
Principal Investigator: Madh Natarajan, MD            
Southlake Hospital Not yet recruiting
Newmarket, Ontario, Canada, L3Y 2P9
Contact: Charles Peniston, MD     905-895-4521 ext 2546     cmpeniston@gmail.com    
Contact: Wendy Wiley, RN     905-895-4521 ext 2546     WWiley@southlakeregional.org    
Principal Investigator: Charles Peniston, MD            
Toronto General Hospital Not yet recruiting
Toronto, Ontario, Canada, M5G 2C4
Contact: Eric Horlick, MD     416-340-3835     eric.horlick@mac.com    
Contact: Nadia Asif, RN     (416) 340-3111     nadia.asif@uhn.on.ca    
Principal Investigator: Eric Horlick, MD            
Canada, Quebec
Centre Hospitalier De Universite of Montreal Not yet recruiting
Montreal, Quebec, Canada, H2W 1T8
Contact: Jean-Bernard Masson, MD     514-890-8000 ext 15160     jbernard.masson@gmail.com    
Contact: Carole Lemay, RN     514-890-8000 ext 14803     carole.lemay.chum@ssss.gouv.qc.ca    
Principal Investigator: Jean-Bernard Masson, MD            
Montreal Heart Institute Not yet recruiting
Montreal, Quebec, Canada, H1T 1CB
Contact: Phillippe Demers, MD     514-593-2556     demersph@gmail.com    
Contact: Jonathan Lacharité, RN     514-376-3330     Jonathan.Lacharite@icm-mhi.org    
Principal Investigator: Phillippe Demers, MD            
Hospital Laval Not yet recruiting
Sainte-Foy, Quebec, Canada, G1V 4G5
Contact: Josep Rodes-Cabau, MD     418-656-4657     Josep.Rodes@criucpq.ulaval.ca    
Contact: Kathia Desmeules, RN     418-656-8711 ext 3039     Kathia.Desmeules@criucpq.ulaval.ca    
Principal Investigator: Joseph Rodes-Cabau, MD            
Czech Republic
University of Hradec Kralove Active, not recruiting
Hradec Kralove, Czech Republic, 5005 05
Denmark
Aarhus University Hospital Recruiting
Aarhus, Denmark, 8200
Contact: Henning Rud Andersen, MD     +45 89 49 61 11     henning.rud.andersen@dadlnet.dk    
Principal Investigator: Henning Rud Andersen, MD            
Finland
Helsinki University Central Hospital Recruiting
Helsinki, Finland, FIN-00029 HUS
Contact: Leo Ihlberg, Prof     +358 50 427 22 87     leo.ihlberg@hus.fi    
Principal Investigator: Leo Ihlberg, Prof            
Tampere University Hospital Active, not recruiting
Tampere, Finland, 33521
France
CHU Jean Minjoz Active, not recruiting
Besançon, France, 25030
CHU La Cavalle Blanche Active, not recruiting
Brest, France, 29609
Hôpital Privé Parly II Active, not recruiting
Le Chesnay, France, 78150
Centre Chirurgical Marie Lannelongue Active, not recruiting
Le Plessis Robinson, France, 92350
CHU La Timone Active, not recruiting
Marseille, France, 13005
Hôpital St Joseph Recruiting
Marseille, France, 13008
Contact: Patrick Joly, MD         pjoly@cardiovista.fr    
Principal Investigator: Patrick Joly, MD            
Clinique Clairval Active, not recruiting
Marseille, France, 13009
Institut Hospitalier Jacques Cartier Recruiting
Massy, France, 91300
Contact: Thierry Lefevre, MD     +33 1 60 13 46 02     t.lefevre@icps.com.fr    
Principal Investigator: Thierry Lefevre, MD            
CHU Montpellier - Hôpital Arnaud de Villeneuve Active, not recruiting
Montpellier, France, 34295
Hopital Nord Laënnec Active, not recruiting
Nantes, France, 44093
Hopital Bichat Recruiting
Paris, France, 75018
Contact: Alec Vahanian, Prof.     +33 1 40 25 67 60     alec.vahanian@bch.aphp.fr    
Principal Investigator: Alec Vahanian, Prof.            
CHRU Pontchaillou Recruiting
Rennes, France, 35000
Contact: Hervé Le Breton, Prof     0033 299 282 505     Herve.LeBreton@chu-rennes.fr    
Contact: Jean Philippe Verhoye, Pr MD, PhD     0033 299 282 490     Jean-philippe.verhoye@chu-rennes.fr    
Principal Investigator: Hervé Hervé Le Breton, Prof            
C.H.U Charles Nicolle Recruiting
Rouen, France, 76000
Contact: Helene Eltchaninoff, Prof.     +33 2 32 88 67 29     Helene.Eltchaninoff@chu-rouen.fr    
Principal Investigator: Helene Eltchaninoff, Prof.            
Clinique Pasteur / GCVI Recruiting
Toulouse, France, 31076
Contact: Jean Fajadet, MD     +33 5 62 21 16 99     j.fajadet@clinique-pasteur.com    
Principal Investigator: Jean Fajadet, MD            
CHU Rangueil Recruiting
Toulouse, France, 31059
Contact: Didier Carrie, Prof.     +33 5 61 32 39 49     carrie.d@chu-toulouse.fr    
Principal Investigator: Didier Carrie, Prof.            
Clinique Saint-Gatien Active, not recruiting
Tours, France, 37000
Germany
Zentralklinik Bad Berka GmbH Active, not recruiting
Bad Berka, Germany, 99437
Herz-Zentrum Bad Krozingen Recruiting
Bad Krozingen, Germany, 79189
Contact: Heinz Joachim Buttner, MD     +49 7633 402-5051     achim.buettner@herzzentrum.de    
Principal Investigator: Heinz Joachim Buttner, MD            
Kerckhoff Klinik Recruiting
Bad Nauheim, Germany, 61231
Contact: Helge Moellmann, MD     +49 6032 9960     h.moellmann@kerckhoff-klinik.de    
Principal Investigator: Helge Moellmann, MD            
Herz- und Gefäss-Klinik GmbH Active, not recruiting
Bad Neustadt, Germany, 97616
Herz- und Diabeteszentrum NRW Active, not recruiting
Bad Oyenhausen, Germany, 32545
Evangelisch Freikirchliches Krankenhaus Active, not recruiting
Bernau, Germany, 16321
Städtisches Klinikum Active, not recruiting
Dortmund, Germany, 44137
Herzzentrum Dresden GmbH Universitätsklinik Recruiting
Dresden, Germany, 01307
Contact: Klaus Matschke, Prof     +49 351 450 1801     K.Matschke@herzzentrum-dresden.com    
Principal Investigator: Klaus Matschke, Prof            
Universitätsklinik Erlangen Active, not recruiting
Erlangen, Germany, 91054
Universitätsklinikum Essen Recruiting
Essen, Germany, 45147
Contact: Matthias Thielmann, MD     +49 201 723 849 27     matthias.thielmann@uni-due.de    
Contact: Philipp Kahlert, MD     +49 201 723 4805     Philipp.Kahlert@uk-essen.de    
Principal Investigator: Matthias Thielmann, MD            
Principal Investigator: Philipp Kahlert, MD            
Universitatsmedizin Gottingen Active, not recruiting
Göttingen, Germany, 37075
Universitatsklinikum Eppendorf Recruiting
Hamburg, Germany, 20246
Contact: Hendrik Treede, MD     +49 40 42803 6586     treede@uke.de    
Principal Investigator: Hendrik Treede, MD            
Asklepios Klinik St Georg Recruiting
Hamburg, Germany, 20099
Contact: Ulrich Schafer, MD     +49 401 818 854 473     ul.schaefer@asklepios.com    
Principal Investigator: Ulrich Schafer, MD            
Universitätsklinikum Active, not recruiting
Jena, Germany, 07747
KLINIKUM KARLSBURG der Klinikgruppe Dr. Guth GmbH & Co. KG Recruiting
Karlsburg, Germany, 17495
Contact: Georg Wollert, Prof     +49 38355 70-1330     prof.wollert@drguth.de    
Principal Investigator: Georg Wollert, Prof            
Städtliche Klinikum Karlsruhe Recruiting
Karlsruhe, Germany, 76133
Contact: Gerhard Schymik, MD     +49 721 974 29 10     gerhard.schymik@klinikum-karlsruhe.de    
Contact: Holger Schroefel, MD     +49 721 973 81 12     chir.schroefel@herzchirurgie-karlsruhe.de    
Principal Investigator: Gerhard Schymik, MD            
Principal Investigator: Holger Schroefel, MD            
Universitätsklinikum Schleswig-Holstein, Campus Kiel Recruiting
Kiel, Germany, 24105
Contact: Georg Lutter, Prof     +49431 597-4562     georg.lutter@uksh-kiel.de    
Principal Investigator: Georg Lutter, Prof            
Universitätsklinikum Active, not recruiting
Köln, Germany, 50937
Herzzentrum Leipzig GmbH Recruiting
Leipzig, Germany, 04289
Contact: Friedrich-Willhelm Mohr, MD     +49 34 1865 1421     mohrf@medizin.uni-leipzig.de    
Contact: Gerhard Schuler, MD     +49 34 1865 1421     gerhard.schuler@med.uni-leipzig.de    
Principal Investigator: Friedrich-Willhelm Mohr, MD            
Principal Investigator: Gerhard Schuler, MD            
Johannes Gutenberg Universität Mainz Active, not recruiting
Mainz, Germany, 55131
Universitätsklinikum Münster Recruiting
Muenster, Germany, 48149
Contact: Helmut Baumgartner, MD     +49 251 8346 111     helmut.baumgartner@ukmuenster.de    
Principal Investigator: Helmut Baumgartner, MD            
Klinikum der Universität München - Großhadern Recruiting
Munich, Germany, 81377
Contact: Christoph Schmitz, MD     +49 89 70 95 29 30     christoph.schmitz@med.uni-muenchen.de    
Contact: Christian Kupatt, MD     +49 89 7095 6092     christian.kupatt@med.uni-muenchen.de    
Principal Investigator: Christoph Schmitz, MD            
Principal Investigator: Christian Kupatt, MD            
Klinikum Schwabing Active, not recruiting
Munich, Germany, 80804
Klinikum Bogenhausen Recruiting
Munich, Germany, 81925
Contact: Markus Kasel, MD, PhD     +49 89 9270 2231     markus_kasel@web.de    
Contact: Walter Eichinger, MD,Phd     +49 89 9270 2631     walter.eichinger@klinikum-muenchen.de    
Principal Investigator: Markus Kasel, Dr., PhD            
Principal Investigator: Walter Eichinger, Dr., PhD            
Deutsches Herzzentrum Muenchen Active, not recruiting
Munich, Germany, 80636
Klinikum Sud Nurnberg Active, not recruiting
Nurnberg, Germany, 90471
Universitatsklinikum Regensburg Recruiting
Regensburg, Germany, 93053
Contact: Christian Hengstenberg, MD     +49 941 944 7258     Christian.Hengstenberg@klinik.uni-regensburg.de    
Principal Investigator: Christian Hengstenberg, MD            
SANA Herzzentrum Active, not recruiting
Stuttgart, Germany, 70174
Universitatsklinik Wurzburg Active, not recruiting
Wurzburg, Germany, 97080
Greece
Hygeia Hospital Active, not recruiting
Athens, Greece, 15123
Israel
Rambam Medical Center Active, not recruiting
Haifa, Israel, 31095
Shaare Zedek Active, not recruiting
Jerusalem, Israel, 91031
Rabin Medical Center Active, not recruiting
Petach Tikva, Israel, 49100
The Chaim Sheba Medical Center Active, not recruiting
Tel Hashomer, Israel, 52621
Italy
Clinica Sant'Anna Hospital Recruiting
Catanzaro, Italy, 83100
Contact: Mauro Cassese, MD     +39 096 150 702 54     maurocassese@tiscali.it    
Principal Investigator: Mauro Cassese, MD            
Ospedale Pasquinucci Active, not recruiting
Massa, Italy, 54100
Clinica Montevergine Recruiting
Mercogliano, Italy, 83013
Contact: Linda Cota, MD     +39 08 256 890 22     linda_ct@libero.it    
Principal Investigator: Paolo Rubino, MD            
Ospedale San Raffaele Recruiting
Milano, Italy, 20132
Contact: Antonio Colombo, MD     +39 02 264 373 31     colombo.antonio@hsr.it    
Principal Investigator: Antonio Colombo, MD            
Centro Cardiologico Monzino Active, not recruiting
Milano, Italy, 20138
Hesperia Hospital Active, not recruiting
Modena, Italy, 41125
Azienda Ospedaliera Policlinico Universitario Recruiting
Padova, Italy, 35128
Contact: Giambattista Isabella, MD     +390498212322     gb.isabella@gmail.com    
Principal Investigator: Giambattista Isabella, MD            
Istituto Clinico Humanitas Active, not recruiting
Rozzano Milano, Italy, 20089
Ospedale San Giovanni Battista Active, not recruiting
Torino, Italy, 10126
Netherlands
Maastricht UMC+ Recruiting
Maastricht, Netherlands, 6202 AZ
Contact: Leen van Garsse, MD     +31433875070     I.van.garsse@mumc.nl    
Principal Investigator: Leen van Garsse, MD            
Norway
Universitetssykehuset Nord-Norge Active, not recruiting
Tromso, Norway, 9038
Poland
The Cardinal Stefan Wyszyński Institute of Cardiology Active, not recruiting
Warsaw, Poland, 04-628
South Africa
Sunninghill Hospital Active, not recruiting
Johannesburg, Gauteng, South Africa, 2157
St Augustine's Hospital Active, not recruiting
Durban, South Africa, 4001
Panorama Medi-Clinic Active, not recruiting
Grand Rapids, South Africa, 7506
UNITAS Hospital Active, not recruiting
Pretoria, South Africa
Vergelegen Medi-Clinic Active, not recruiting
Somerset West, South Africa, 7130
Spain
C.H.U. A Coruña Active, not recruiting
A Coruña, Spain, 15006
Hospital Universitario Vall Hebron Active, not recruiting
Barcelona, Spain, 8035
Hospital Clinic de Barcelona Active, not recruiting
Barcelona, Spain, 08036
Hospital Clinico San Carlos Recruiting
Madrid, Spain, 28040
Contact: Carlos Macaya, MD     +34 91 330 32 89     cmacaya.hcsc@salud.madrid.org    
Principal Investigator: Carlos Macaya, MD            
Hospital La Paz Active, not recruiting
Madrid, Spain, 28046
Hospital Virgen de Arrixaca Active, not recruiting
Murcia, Spain, 30120
Policlinica Gipuzkoa Active, not recruiting
San Sebastian, Spain, 20009
Hospital Marques de Valdecilla Active, not recruiting
Santander, Spain, 39008
Hospital Virgen Macarena Active, not recruiting
Sevilla, Spain, 41007
Complexo Hospitalario Universitario de Vigo Active, not recruiting
Vigo, Spain, 36200
Switzerland
Inselspital Bern Recruiting
Bern, Switzerland, 3010
Contact: Stephan Windecker, MD     +41 31 632 34 78     Stephan.Windecker@insel.ch    
Principal Investigator: Stephan Windecker, MD            
Klinik im Park Active, not recruiting
Zurich, Switzerland, 8027
United Kingdom
King's College Hospital NHS Foundation Trust Recruiting
London, United Kingdom, SE5 9RS
Contact: Olaf Wendler, PhD     +44 203 299 43 41     olaf.wendler@nhs.net    
Principal Investigator: Olaf Wendler, PhD            
St Thomas Hospital Recruiting
London, United Kingdom, SE1 7EH
Contact: Martyn Thomas, MD     +44 207 188 85 24     mttwins@aol.com    
Principal Investigator: Martyn Thomas, MD            
London Chest Hospital Recruiting
London, United Kingdom, E2 9JX
Contact: Simon Kennon, MD     +44 7881 634246     Simon.Kennon@bartsandthelondon.nhs.uk    
Principal Investigator: Simon Kennon, MD            
St Mary's Hospital - Imperial College Healthcare NHS Trust, Hammersmith Hospital . Du Cane Road Active, not recruiting
London, United Kingdom, W12 0HS
The James Cook University Hospital Active, not recruiting
Middlesbrough, United Kingdom, TS4 3BW
Sponsors and Collaborators
Edwards Lifesciences
Investigators
Principal Investigator: Martyn Thomas, MB BS, FRCP, MD MTTWINS@aol.com
Principal Investigator: Olar Wendler, MD, PhD, FRCS olaf.wendler@kch.nhs.uk
  More Information

No publications provided

Responsible Party: Edwards Lifesciences
ClinicalTrials.gov Identifier: NCT01238497     History of Changes
Other Study ID Numbers: 2010-10
Study First Received: October 26, 2010
Last Updated: September 11, 2012
Health Authority: United Kingdom: Medicines and Healthcare Products Regulatory Agency

Keywords provided by Edwards Lifesciences:
SAPIEN XT™, Transfemoral, NovaFlex, Transapical, Ascendra2, aortic stenosis, aortic valve, Transcatheter Heart Valve, THV

Additional relevant MeSH terms:
Aortic Valve Stenosis
Constriction, Pathologic
Heart Valve Diseases
Heart Diseases
Cardiovascular Diseases
Ventricular Outflow Obstruction
Pathological Conditions, Anatomical

ClinicalTrials.gov processed this record on May 16, 2013