Correlation of Genetic Polymorphism and Livedo Vasculitis
Livedo vasculitis is disease with recurrent courses of painful foot or ankle ulcerations, followed by healed white scars. The actual mechanism of its pathophysiology is not yet clear. It has been reported to be associated with some gene mutations, for example, factor V Leiden gene. This study is aimed to find the possible relation of these gene mutations in Taiwanese patients.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Correlation of Genetic Polymorphism and Livedo Vasculitis|
Buccal mucosa cotton tip swab
|Study Start Date:||October 2007|
|Study Completion Date:||April 2009|
|Primary Completion Date:||April 2009 (Final data collection date for primary outcome measure)|
Livedo vasculitis is a chronic, recurrent painful ulcerations on the ankles and feet. This chronic disease is characterized by healed white, atrophic scars named atrophie blanche. The histopathological exam on the lesion site reveals fibrin deposition within the vessel walls. It has been reported to be related to factor V Leiden mutation (heterozygous) (22.2%), prothrombin G20210A gene mutation (8.3%), PAI promotor 4G/4G genotype and methylenetetrahydrofolate reductase (MTHFR) C677T mutation in about total 30% livedo vasculitis patients. This study is trying to find the correlation between Taiwanese patients and these four genes.
|National Taiwan University Hospital|
|Taipei, Taiwan, 100|
|Principal Investigator:||Tsen-Fang Tsai, MD||National Taiwan University Hospital|