Parkinson's Research: The Organized Genetics Initiative (PROGENI)
This study has been completed.
Sponsor:
Indiana University School of Medicine
Collaborators:
The Parkinson Study Group
Children's Hospital Medical Center, Cincinnati
Information provided by:
Indiana University
ClinicalTrials.gov Identifier:
NCT00086073
First received: June 22, 2004
Last updated: February 15, 2011
Last verified: November 2010
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Purpose
The purpose of this trial is to study genetic and other risk factors that may be important in the development of Parkinson's disease.
| Condition |
|---|
|
Parkinson Disease |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | Parkinson's Disease Collaborative Study of Genetic Linkage |
Resource links provided by NLM:
Further study details as provided by Indiana University:
Biospecimen Retention: Samples With DNA
Detailed Description:
blood sample
| Estimated Enrollment: | 1800 |
| Study Start Date: | August 1998 |
| Study Completion Date: | January 2011 |
The The Parkinson's Research: The Organized Genetics Initiative, also known as PROGENI, is a multi-center study involving 2000 people throughout North America who are affected, or possibly affected, with Parkinson's disease (PD). The goal of the initiative is to study the genetic and other risk factors which may be important in the development of PD.
In order to better understand the genetic factors leading to PD, researchers will study families having 2 or more members diagnosed with PD. Using DNA samples from each participant, researchers hope to identify genes that may cause a person to be at higher risk for developing PD.
Each participant in the study will be asked to complete a family history questionnaire, providing information about the history of PD in the family. Participants also will be asked to discuss the symptoms they have experienced and their responses to PD medications. This information will be used by study personnel to determine further eligibility for the study. Those eligible for further participation will be asked to undergo a study visit at the site closest to their residence, during which they will be asked to complete questionnaires regarding PD symptoms, medical history, places of residence, occupations, mood, mental status, and activity level. A blood sample will be drawn for DNA extraction. The study visit will take about 2 hours.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Study Population
families having 2 or more members diagnosed with PD
Criteria
Inclusion Criteria:
- To be eligible to participate in this study participants must be diagnosed with or have symptoms of PD. In addition, they must also have a family history of PD in other relatives.
Exclusion Criteria:
- Subjects cannot have participated in any other genetic research project for Parkinson's disease.
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00086073
Hide Study Locations
Hide Study LocationsLocations
| United States, Arizona | |
| Barrow Neurological Institute | |
| Phoenix, Arizona, United States, 85013 | |
| United States, California | |
| Parkinson's & Movement Disorder Institute | |
| Fountain Valley, California, United States, 92708 | |
| University of California Irvine | |
| Irvine, California, United States, 92612 | |
| Pacific Neuroscience Medical Group, Inc | |
| Oxnard, California, United States | |
| University of California San Diego | |
| San Diego, California, United States, 92101 | |
| University of California San Francisco | |
| San Francisco, California, United States, 94143 | |
| United States, Colorado | |
| University of Colorado Health Sciences Center | |
| Denver, Colorado, United States, 80262 | |
| Colorado Neurological Institute | |
| Englewood, Colorado, United States, 80113 | |
| United States, Connecticut | |
| Institute for Neurodegenerative Disorders | |
| New Haven, Connecticut, United States, 06510 | |
| United States, Florida | |
| Parkinson's Disease & Mmvt Disorders Ctr of Boca Raton | |
| Boca Raton, Florida, United States | |
| Mayo Clinic Jacksonville | |
| Jacksonville, Florida, United States, 32224 | |
| University of South Florida | |
| Tampa, Florida, United States, 33620 | |
| Cleveland Clinic Florida | |
| Weston, Florida, United States | |
| Cleveland Clinic Florida | |
| Weston, Florida, United States, 33331 | |
| United States, Georgia | |
| Medical College of Georgia | |
| Augusta, Georgia, United States, 30912 | |
| United States, Hawaii | |
| Pacific Health Research Institute | |
| Honolulu, Hawaii, United States | |
| United States, Illinois | |
| Northwestern University Medical School | |
| Chicago, Illinois, United States, 60611 | |
| University of Chicago | |
| Chicago, Illinois, United States, 60637 | |
| Evanston Northwestern Healthcare | |
| Evanston, Illinois, United States, 60026 | |
| Southern Illinois Univ School of Medicine | |
| Springfield, Illinois, United States | |
| United States, Indiana | |
| Indiana University School of Medicine | |
| Indianapolis, Indiana, United States, 46202 | |
| United States, Iowa | |
| University of Iowa | |
| Iowa City, Iowa, United States, 52242 | |
| United States, Kansas | |
| Kansas University Medical Center | |
| Kansas City, Kansas, United States, 66160 | |
| United States, Louisiana | |
| Oschsner Clinic Foundation | |
| New Orleans, Louisiana, United States, 70112 | |
| LSU Health Sciences Center | |
| Shreveport, Louisiana, United States, 71130 | |
| United States, Maine | |
| Port City Neurology, Inc | |
| Scarborough, Maine, United States | |
| United States, Maryland | |
| University of Maryland School of Medicine | |
| Baltimore, Maryland, United States, 21201 | |
| Johns Hopkins University | |
| Baltimore, Maryland, United States | |
| United States, Massachusetts | |
| Beth Israel Deaconess Medical Center | |
| Boston, Massachusetts, United States, 02215 | |
| Brigham & Women's Hospital | |
| Boston, Massachusetts, United States, 02115 | |
| United States, Michigan | |
| Michigan State University | |
| East Lansing, Michigan, United States | |
| Henry Ford Health System | |
| Southfield, Michigan, United States | |
| United States, Minnesota | |
| University of Minnesota Fairview Univ Med Ctr | |
| Minneapolis, Minnesota, United States, 55406 | |
| United States, Missouri | |
| Washington University | |
| St. Louis, Missouri, United States, 63130 | |
| United States, New York | |
| Albany Medical College | |
| Albany, New York, United States, 12208 | |
| University of Buffalo | |
| Buffalo, New York, United States | |
| Mount Sinai Medical Center | |
| New York, New York, United States, 10029 | |
| Beth Israel Medical Center | |
| New York, New York, United States, 10003 | |
| Columbia-Presbyterian Medical Center | |
| New York, New York, United States, 10032 | |
| University of Rochester Medical Center | |
| Rochester, New York, United States, 14642 | |
| United States, North Carolina | |
| Wake Forest University School of Medicine | |
| Winston-Salem, North Carolina, United States, 27157 | |
| United States, Ohio | |
| University of Cincinnati Medical Center | |
| Cincinnati, Ohio, United States, 45267 | |
| Cleveland Clinic Foundation | |
| Cleveland, Ohio, United States | |
| Ohio State University | |
| Columbus, Ohio, United States, 43210 | |
| Medical College of Ohio, , | |
| Toledo, Ohio, United States, 43614 | |
| United States, Oregon | |
| Oregon Health & Science University | |
| Portland, Oregon, United States, 97239 | |
| United States, Pennsylvania | |
| University of Pittsburg | |
| Pittsburg, Pennsylvania, United States | |
| United States, Rhode Island | |
| Neurohealth | |
| Warwick, Rhode Island, United States, 02886 | |
| United States, Tennessee | |
| University of Tennessee-Health Sciences Center | |
| Memphis, Tennessee, United States, 38163 | |
| United States, Texas | |
| UT Southwestern Medical Center | |
| Dallas, Texas, United States, 75390 | |
| Baylor College of Medicine | |
| Houston, Texas, United States, 77030 | |
| United States, Wisconsin | |
| Medical College of Wisconsin | |
| Milwaukee, Wisconsin, United States, 53226 | |
| Canada, Alberta | |
| University of Alberta | |
| Edmonton, Alberta, Canada | |
| Canada, Ontario | |
| London Health Sciences Center | |
| London, Ontario, Canada | |
| Ottawa Civic Hospital | |
| Ottawa, Ontario, Canada | |
| Toronto Western Hospital | |
| Toronto, Ontario, Canada | |
| Canada, Quebec | |
| Hotel-Dieu Hospital-CHUM | |
| Montreal, Quebec, Canada | |
| Puerto Rico | |
| University of Puerto Rico School of Medicine | |
| San Juan, Puerto Rico | |
Sponsors and Collaborators
Indiana University School of Medicine
The Parkinson Study Group
Children's Hospital Medical Center, Cincinnati
Investigators
| Principal Investigator: | Tatiana Foroud, Ph.D. | Indiana University |
More Information
Additional Information:
No publications provided
| Responsible Party: | Tatiana Foroud, Ph.D, Principal Investigator, Indiana University |
| ClinicalTrials.gov Identifier: | NCT00086073 History of Changes |
| Other Study ID Numbers: | 9703-09, R01NS37167 |
| Study First Received: | June 22, 2004 |
| Last Updated: | February 15, 2011 |
| Health Authority: | United States: Federal Government |
Keywords provided by Indiana University:
|
Parkinson disease Parkinson's disease PD genetics |
genes siblings family |
Additional relevant MeSH terms:
|
Parkinson Disease Parkinsonian Disorders Basal Ganglia Diseases Brain Diseases |
Central Nervous System Diseases Nervous System Diseases Movement Disorders Neurodegenerative Diseases |
ClinicalTrials.gov processed this record on May 21, 2013