Radiation Therapy in Treating Patients With Bone Metastases From Breast or Prostate Cancer
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Purpose
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known which radiation therapy regimen is more effective for bone metastases.
PURPOSE: Randomized phase III trial to compare different radiation therapy regimens in treating patients who have bone metastases from breast or prostate cancer.
| Condition | Intervention | Phase |
|---|---|---|
|
Breast Cancer Metastatic Cancer Pain Prostate Cancer |
Procedure: pain therapy Radiation: radiation therapy |
Phase 3 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Primary Purpose: Supportive Care |
| Official Title: | Randomized Trial of Palliative Radiation Therapy for Osseous Metastases: A Study of Palliation of Symptoms and Quality of Life |
| Estimated Enrollment: | 938 |
| Study Start Date: | February 1998 |
| Primary Completion Date: | February 2009 (Final data collection date for primary outcome measure) |
OBJECTIVES:
- Compare the ability of a single fraction of radiation therapy vs multiple fractions to provide complete pain relief in patients with painful bone metastases from breast or prostate cancer.
- Determine the frequency and duration of pain relief and narcotic relief after these treatments in these patient populations.
- Compare the effect on quality of life of these two treatments in these patient populations.
- Compare the incidence of pathologic fracture within the treatment fields after these two treatments in these patient populations.
OUTLINE: This is a randomized study.
Patients are assigned to 1 of 2 treatment arms. Arm I consists of radiation therapy delivered in 10 fractions over 2 weeks. Arm II consists of a single dose of radiation therapy. Any retreatment does not occur until at least 4 weeks after prior treatment unless there is an increase of 2 points on the pain score.
Patients are followed and quality of life is assessed at 2 and 4 weeks, then at 2, 3, 6, 9, and 12 months, every 6 months for the next 3 years, then annually until death.
PROJECTED ACCRUAL: This study will accrue 938 patients within 2 years.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
- Histologically proven breast or prostate cancer
- Radiographic evidence of bone metastasis within 8 weeks of study
Eligible treatment sites:
Weight bearing sites:
- Pelvis (excluding pubis)
- Femur
- Sacrum and/or sacroiliac joints
- Tibia
Nonweight bearing sites:
- Up to 5 consecutive cervical, thoracic, or lumbar vertebral bodies
- Lumbosacral spine
- Up to 3 consecutive ribs
- Humerus
- Fibula
- Radius with/without ulna
- Clavicle
- Scapula
- Pubis
- If multiple sites are treated, site is included as weight bearing if any of the sites include the pelvis, sacrum, femur, or tibia
- Worst pain score of at least 5 on a scale of 10
- No skull, feet, or hand metastases
- No spinal cord or cauda equina compression/effacement in vertebral metastases
- Multiple sites eligible if they can be included in no greater than 3 treatment sites
PATIENT CHARACTERISTICS:
Age:
- 18 and over
Performance status:
- Karnofsky 40-100%
Life expectancy:
- At least 3 months
Hematopoietic:
- Not specified
Hepatic:
- Not specified
Renal:
- Not specified
Other:
- No impending fracture of the treatment site
- No hematologic primary malignancies
- Negative pregnancy test
PRIOR CONCURRENT THERAPY:
Biologic therapy:
- No change in immunotherapy within 30 days
Chemotherapy:
- No change in chemotherapy within 30 days
Endocrine therapy:
- No change in hormonal therapy within 30 days
Radiotherapy:
- No prior radiation therapy to treatment area
- At least 30 days since systemic radiotherapy (Sr 89)
Surgery:
- No prior palliative surgery to treatment area
- No planned surgical fixation of the bone
Contacts and Locations
Hide Study Locations| United States, Alabama | |
| University of Alabama at Birmingham Comprehensive Cancer Center | |
| Birmingham, Alabama, United States, 35294-3300 | |
| Comprehensive Cancer Institute of Huntsville | |
| Huntsville, Alabama, United States, 35801 | |
| Huntsville Hospital System | |
| Huntsville, Alabama, United States, 35801-4470 | |
| MBCCOP - Gulf Coast | |
| Mobile, Alabama, United States, 36688 | |
| Alabama Oncology, LLC | |
| Montgomery, Alabama, United States, 36106-2801 | |
| Radiation Oncology Associates of West Alabama | |
| Tuscaloosa, Alabama, United States, 35401 | |
| United States, Arizona | |
| Foundation for Cancer Research and Education | |
| Phoenix, Arizona, United States, 85013 | |
| CCOP - Scottsdale Oncology Program | |
| Scottsdale, Arizona, United States, 85259-5404 | |
| United States, California | |
| Mount Diablo Medical Center | |
| Concord, California, United States, 94524-4110 | |
| Cancer Center and Beckman Research Institute, City of Hope | |
| Duarte, California, United States, 91010-3000 | |
| California Cancer Center | |
| Fresno, California, United States, 93720 | |
| Saint Agnes Cancer Center | |
| Fresno, California, United States, 93720 | |
| Sutter Health West Cancer Research Group | |
| Greenbrae, California, United States, 94904 | |
| Loma Linda University Medical Center | |
| Loma Linda, California, United States, 92354 | |
| Veterans Affairs Medical Center - Long Beach | |
| Long Beach, California, United States, 90822 | |
| Jonsson Comprehensive Cancer Center, UCLA | |
| Los Angeles, California, United States, 90095-1781 | |
| USC/Norris Comprehensive Cancer Center and Hospital | |
| Los Angeles, California, United States, 90033-0804 | |
| CCOP - Bay Area Tumor Institute | |
| Oakland, California, United States, 94609-3305 | |
| Huntington Cancer Center | |
| Pasadena, California, United States, 91105 | |
| Cancer Care Center | |
| Pomona, California, United States, 91767 | |
| Radiation Oncology Center - Sacramento | |
| Sacramento, California, United States, 95816 | |
| Radiation Medical Group, Inc. | |
| San Diego, California, United States, 92101-1492 | |
| UCSF Cancer Center and Cancer Research Institute | |
| San Francisco, California, United States, 94143-0128 | |
| O'Connor Hospital | |
| San Jose, California, United States, 95128 | |
| CCOP - Santa Rosa Memorial Hospital | |
| Santa Rosa, California, United States, 95403 | |
| St. Joseph's Regional Health System | |
| Stockton, California, United States, 95204 | |
| David Grant Medical Center | |
| Travis Air Force Base, California, United States, 94535 | |
| United States, Colorado | |
| Memorial Hospital Cancer Center | |
| Colorado Springs, Colorado, United States, 80909 | |
| University of Colorado Cancer Center | |
| Denver, Colorado, United States, 80010 | |
| Saint Mary's Hospital and Medical Center | |
| Grand Junction, Colorado, United States, 81502 | |
| United States, Delaware | |
| CCOP - Christiana Care Health Services | |
| Wilmington, Delaware, United States, 19899 | |
| United States, District of Columbia | |
| Howard University Cancer Center | |
| Washington, District of Columbia, United States, 20060 | |
| United States, Florida | |
| University of Florida Health Science Center | |
| Gainesville, Florida, United States, 32610-0296 | |
| Mayo Clinic | |
| Jacksonville, Florida, United States, 32224 | |
| Edna Williams Cancer Treatment Center | |
| Jacksonville, Florida, United States, 32207 | |
| Health First Holmes Regional Medical Center | |
| Melbourne, Florida, United States, 32901 | |
| Baptist Hospital of Miami | |
| Miami, Florida, United States, 33176-2197 | |
| Veterans Affairs Medical Center - Miami | |
| Miami, Florida, United States, 33125 | |
| Sylvester Cancer Center, University of Miami | |
| Miami, Florida, United States, 33136 | |
| CCOP - Mount Sinai Medical Center | |
| Miami Beach, Florida, United States, 33140 | |
| MD Anderson Cancer Center Orlando | |
| Orlando, Florida, United States, 32806 | |
| Gulf Coast Cancer Treatment Center | |
| Panama City, Florida, United States, 32405-4587 | |
| Bay Medical Center | |
| Panama City, Florida, United States, 32401 | |
| Sarasota Radiation and Medical Oncology Center | |
| Sarasota, Florida, United States, 34233 | |
| Tallahassee Memorial Healthcare | |
| Tallahassee, Florida, United States, 32308 | |
| H. Lee Moffitt Cancer Center and Research Institute | |
| Tampa, Florida, United States, 33612-9497 | |
| United States, Georgia | |
| CCOP - Atlanta Regional | |
| Atlanta, Georgia, United States, 30342-1701 | |
| Emory University Hospital - Atlanta | |
| Atlanta, Georgia, United States, 30322 | |
| Medical Center/John B. Amos Community Cancer Center | |
| Columbus, Georgia, United States, 31902 | |
| Regional Radiation Oncology Center at Rome | |
| Rome, Georgia, United States, 30165 | |
| United States, Hawaii | |
| MBCCOP - Hawaii | |
| Honolulu, Hawaii, United States, 96813 | |
| United States, Illinois | |
| Northwest Community Hospital | |
| Arlington Heights, Illinois, United States, 60005 | |
| Northwestern Memorial Hospital | |
| Chicago, Illinois, United States, 60611 | |
| CCOP - Central Illinois | |
| Decatur, Illinois, United States, 62526 | |
| Ingalls Memorial Hospital | |
| Harvey, Illinois, United States, 60426 | |
| Loyola University Medical Center | |
| Maywood, Illinois, United States, 60153 | |
| Lutheran General Cancer Care Center | |
| Park Ridge, Illinois, United States, 60068 | |
| Methodist Medical Center of Illinois | |
| Peoria, Illinois, United States, 61636 | |
| CCOP - Illinois Oncology Research Association | |
| Peoria, Illinois, United States, 61602 | |
| CCOP - Carle Cancer Center | |
| Urbana, Illinois, United States, 61801 | |
| United States, Indiana | |
| St. John's Medical Center | |
| Anderson, Indiana, United States, 46016 | |
| Bloomington Hospital | |
| Bloomington, Indiana, United States, 47402 | |
| Veterans Affairs Medical Center - Indianapolis (Roudebush) | |
| Indianapolis, Indiana, United States, 46202 | |
| Clarian Health Partners Inc. | |
| Indianapolis, Indiana, United States, 46206-1367 | |
| Regional Cancer Center | |
| Indianapolis, Indiana, United States, 46219 | |
| Oncology Institute of Greater Lafayette | |
| Lafayette, Indiana, United States, 47904 | |
| Ball Memorial Hospital | |
| Muncie, Indiana, United States, 47303-3499 | |
| CCOP - Northern Indiana CR Consortium | |
| South Bend, Indiana, United States, 46601 | |
| United States, Iowa | |
| CCOP - Cedar Rapids Oncology Project | |
| Cedar Rapids, Iowa, United States, 52403-1206 | |
| CCOP - Iowa Oncology Research Association | |
| Des Moines, Iowa, United States, 50309-1016 | |
| Wendt Regional Cancer Center of Finley Hospital | |
| Dubuque, Iowa, United States, 52001 | |
| Siouxland Hematology-Oncology | |
| Sioux City, Iowa, United States, 51101-1733 | |
| United States, Kansas | |
| CCOP - Wichita | |
| Wichita, Kansas, United States, 67214-3882 | |
| United States, Kentucky | |
| Albert B. Chandler Medical Center, University of Kentucky | |
| Lexington, Kentucky, United States, 40536-0084 | |
| Central Baptist Hospital | |
| Lexington, Kentucky, United States, 40503 | |
| Lexington Clinic Cancer Center | |
| Lexington, Kentucky, United States, 40504 | |
| Louisville Radiation Oncology | |
| Louisville, Kentucky, United States, 40215 | |
| James Graham Brown Cancer Center | |
| Louisville, Kentucky, United States, 40202 | |
| Merle M. Mahr Cancer Center | |
| Madisonville, Kentucky, United States, 42431 | |
| United States, Louisiana | |
| Mary Bird Perkins Cancer Center | |
| Baton Rouge, Louisiana, United States, 70809 | |
| CCOP - Ochsner | |
| New Orleans, Louisiana, United States, 70121 | |
| MBCCOP - LSU Health Sciences Center | |
| New Orleans, Louisiana, United States, 70112 | |
| Tulane University School of Medicine | |
| New Orleans, Louisiana, United States, 70112 | |
| United States, Maine | |
| Maine Medical Center | |
| Portland, Maine, United States, 04102 | |
| United States, Maryland | |
| Anne Arundel Oncology Center | |
| Annapolis, Maryland, United States, 21401 | |
| Greater Baltimore Medical Center and Cancer Center | |
| Baltimore, Maryland, United States, 21204 | |
| Sinai Hospital of Baltimore | |
| Baltimore, Maryland, United States, 21225 | |
| Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | |
| Baltimore, Maryland, United States, 21231-2410 | |
| Harbor Hospital Center | |
| Baltimore, Maryland, United States, 21225 | |
| Peninsula Regional Medical Center | |
| Salisbury, Maryland, United States, 21801 | |
| United States, Massachusetts | |
| Cape Cod Hospital | |
| Hyannis, Massachusetts, United States, 02601 | |
| Veterans Affairs Medical Center - Boston (Jamaica Plain) | |
| Jamaica Plain, Massachusetts, United States, 02130 | |
| United States, Michigan | |
| University of Michigan Comprehensive Cancer Center | |
| Ann Arbor, Michigan, United States, 48109-0752 | |
| CCOP - Ann Arbor Regional | |
| Ann Arbor, Michigan, United States, 48106 | |
| Barbara Ann Karmanos Cancer Institute | |
| Detroit, Michigan, United States, 48201-1379 | |
| Henry Ford Hospital | |
| Detroit, Michigan, United States, 48202 | |
| Hurley Medical Center | |
| Flint, Michigan, United States, 48503 | |
| McLaren Regional Cancer Center | |
| Flint, Michigan, United States, 48432 | |
| CCOP - Kalamazoo | |
| Kalamazoo, Michigan, United States, 49007-3731 | |
| Marquette General Hospital | |
| Marquette, Michigan, United States, 49855 | |
| MidMichigan Medical Center - Midland | |
| Midland, Michigan, United States, 48670 | |
| William Beaumont Hospital | |
| Royal Oak, Michigan, United States, 48073 | |
| William Beaumont Hospital - Troy | |
| Troy, Michigan, United States, 48098 | |
| United States, Minnesota | |
| Mayo Clinic Cancer Center | |
| Rochester, Minnesota, United States, 55905 | |
| CCOP - Metro-Minnesota | |
| Saint Louis Park, Minnesota, United States, 55416 | |
| United States, Missouri | |
| Ellis Fischel Cancer Center - Columbia | |
| Columbia, Missouri, United States, 65203 | |
| CCOP - Kansas City | |
| Kansas City, Missouri, United States, 64131 | |
| Mallinckrodt Institute of Radiology | |
| Saint Louis, Missouri, United States, 63108 | |
| St. Louis University Health Sciences Center | |
| Saint Louis, Missouri, United States, 63110-0250 | |
| Cancer Research for the Ozarks | |
| Springfield, Missouri, United States, 65807 | |
| CCOP - Cancer Research for the Ozarks | |
| Springfield, Missouri, United States, 65807 | |
| United States, Montana | |
| CCOP - Montana Cancer Consortium | |
| Billings, Montana, United States, 59101 | |
| United States, Nebraska | |
| CCOP - Missouri Valley Cancer Consortium | |
| Omaha, Nebraska, United States, 68106 | |
| Methodist Cancer Center - Omaha | |
| Omaha, Nebraska, United States, 68114 | |
| Nebraska Health System | |
| Omaha, Nebraska, United States, 68198-7460 | |
| United States, Nevada | |
| CCOP - Southern Nevada Cancer Research Foundation | |
| Las Vegas, Nevada, United States, 89106 | |
| United States, New Hampshire | |
| Norris Cotton Cancer Center | |
| Lebanon, New Hampshire, United States, 03756-0002 | |
| Elliot Regional Cancer Center | |
| Manchester, New Hampshire, United States, 03103 | |
| United States, New Jersey | |
| Cooper Cancer Institute | |
| Camden, New Jersey, United States, 08103 | |
| Veterans Affairs Medical Center - East Orange | |
| East Orange, New Jersey, United States, 07018-1095 | |
| John F. Kennedy Medical Center | |
| Edison, New Jersey, United States, 08818 | |
| Trinitas Hospital - Jersey Street Campus | |
| Elizabeth, New Jersey, United States, 07201 | |
| Kimball Medical Center | |
| Lakewood, New Jersey, United States, 08701 | |
| Monmouth Medical Center | |
| Long Branch, New Jersey, United States, 07740-6395 | |
| South Jersey Regional Cancer Center | |
| Millville, New Jersey, United States, 08332 | |
| Fox Chase Cancer Center at Virtua Memorial Hospital Burlington County | |
| Mount Holly, New Jersey, United States, 08060 | |
| Cancer Institute of New Jersey | |
| New Brunswick, New Jersey, United States, 08903 | |
| Newark Beth Israel Medical Center | |
| Newark, New Jersey, United States, 07112 | |
| Atlantic City Medical Center | |
| Pomona, New Jersey, United States, 08240 | |
| Valley Hospital | |
| Ridgewood, New Jersey, United States, 07450 | |
| Community Medical Center | |
| Toms River, New Jersey, United States, 08755 | |
| Capital Health System at Mercer | |
| Trenton, New Jersey, United States, 08607 | |
| St. Francis Medical Center | |
| Trenton, New Jersey, United States, 08629 | |
| Associated Radiologists, P.A. | |
| Warren, New Jersey, United States, 07059 | |
| United States, New Mexico | |
| Radiation Oncology Associates of Albuquerque | |
| Albuquerque, New Mexico, United States, 87109 | |
| United States, New York | |
| Cancer Center of Albany Medical Center | |
| Albany, New York, United States, 12208 | |
| Lourdes Regional Cancer Center | |
| Binghamton, New York, United States, 13905 | |
| State University of New York Health Science Center at Brooklyn | |
| Brooklyn, New York, United States, 11203 | |
| New York Methodist Hospital | |
| Brooklyn, New York, United States, 11215-3609 | |
| Finger Lakes Radiation Oncology Center | |
| Clifton Springs, New York, United States, 14432 | |
| CCOP - North Shore University Hospital | |
| Manhasset, New York, United States, 11030 | |
| Memorial Sloan-Kettering Cancer Center | |
| New York, New York, United States, 10021 | |
| Herbert Irving Comprehensive Cancer Center | |
| New York, New York, United States, 10032 | |
| Champlain Valley Physicians Hospital Medical Center | |
| Plattsburgh, New York, United States, 12901 | |
| Vassar Brothers Hospital | |
| Poughkeepsie, New York, United States, 12601 | |
| University of Rochester Cancer Center | |
| Rochester, New York, United States, 14642 | |
| North Shore Radiation Oncology | |
| Setauket, New York, United States, 11733 | |
| State University of New York - Upstate Medical University | |
| Syracuse, New York, United States, 13210 | |
| CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C. | |
| Syracuse, New York, United States, 13217 | |
| Riverhill Radiation Oncology | |
| Yonkers, New York, United States, 10701 | |
| United States, North Carolina | |
| Lineberger Comprehensive Cancer Center, UNC | |
| Chapel Hill, North Carolina, United States, 27599-7295 | |
| Northeast Medical Center | |
| Concord, North Carolina, United States, 28025 | |
| East Carolina University School of Medicine | |
| Greenville, North Carolina, United States, 27858-4354 | |
| Rex Healthcare | |
| Raleigh, North Carolina, United States, 27607 | |
| Comprehensive Cancer Center at Wake Forest University | |
| Winston-Salem, North Carolina, United States, 27157-1082 | |
| CCOP - Southeast Cancer Control Consortium | |
| Winston-Salem, North Carolina, United States, 27104-4241 | |
| United States, North Dakota | |
| Medcenter One Health System | |
| Bismarck, North Dakota, United States, 58501 | |
| Trinity Cancer Care Center | |
| Minot, North Dakota, United States, 58701 | |
| United States, Ohio | |
| Akron City Hospital | |
| Akron, Ohio, United States, 44309 | |
| Akron General Medical Center | |
| Akron, Ohio, United States, 44302 | |
| Christ Hospital | |
| Cincinnati, Ohio, United States, 45219 | |
| Barrett Cancer Center, The University Hospital | |
| Cincinnati, Ohio, United States, 45267-0502 | |
| Cleveland Clinic Taussig Cancer Center | |
| Cleveland, Ohio, United States, 44195 | |
| Cleveland Clinic Foundation | |
| Cleveland, Ohio, United States, 44195-5044 | |
| University Hospitals of Cleveland | |
| Cleveland, Ohio, United States, 44106 | |
| Ireland Cancer Center | |
| Cleveland, Ohio, United States, 44106-5065 | |
| Arthur G. James Cancer Hospital - Ohio State University | |
| Columbus, Ohio, United States, 43210-1240 | |
| CCOP - Columbus | |
| Columbus, Ohio, United States, 43206 | |
| CCOP - Dayton | |
| Kettering, Ohio, United States, 45429 | |
| CCOP - Toledo Community Hospital Oncology Program | |
| Toledo, Ohio, United States, 43623-3456 | |
| United States, Oklahoma | |
| St. Anthony Hospital | |
| Oklahoma City, Oklahoma, United States, 73101 | |
| University of Oklahoma Health Sciences Center | |
| Oklahoma City, Oklahoma, United States, 73190 | |
| St. John Health System | |
| Tulsa, Oklahoma, United States, 74104 | |
| United States, Oregon | |
| CCOP - Columbia River Program | |
| Portland, Oregon, United States, 97213 | |
| United States, Pennsylvania | |
| Lehigh Valley Hospital | |
| Allentown, Pennsylvania, United States, 18103 | |
| St. Luke's Hospital Regional Cancer Center | |
| Bethlehem, Pennsylvania, United States, 18015 | |
| Geisinger Medical Center | |
| Danville, Pennsylvania, United States, 17822-2001 | |
| Mercy Fitzgerald Hospital | |
| Darby, Pennsylvania, United States, 19023 | |
| Delaware County Memorial Hospital | |
| Drexel Hill, Pennsylvania, United States, 19026 | |
| Pocono Cancer Center | |
| East Stroudsburg, Pennsylvania, United States, 18301 | |
| Milton S. Hershey Medical Center | |
| Hershey, Pennsylvania, United States, 17033-0850 | |
| Fox Chase Cancer Center | |
| Philadelphia, Pennsylvania, United States, 19111 | |
| Albert Einstein Cancer Center | |
| Philadelphia, Pennsylvania, United States, 19141 | |
| Kimmel Cancer Center of Thomas Jefferson University - Philadelphia | |
| Philadelphia, Pennsylvania, United States, 19107-5541 | |
| University of Pennsylvania Cancer Center | |
| Philadelphia, Pennsylvania, United States, 19104-4283 | |
| Veterans Affairs Medical Center - Philadelphia | |
| Philadelphia, Pennsylvania, United States, 19104 | |
| University of Pittsburgh Cancer Institute | |
| Pittsburgh, Pennsylvania, United States, 15213-3489 | |
| Allegheny General Hospital | |
| Pittsburgh, Pennsylvania, United States, 15212-4772 | |
| Mercy Hospital of Pittsburgh | |
| Pittsburgh, Pennsylvania, United States, 15219 | |
| Western Pennsylvania Hospital | |
| Pittsburgh, Pennsylvania, United States, 15224 | |
| Reading Hospital and Medical Center | |
| Reading, Pennsylvania, United States, 19612-6052 | |
| Mercy Hospital Cancer Center - Scranton | |
| Scranton, Pennsylvania, United States, 18501 | |
| Wilkes Barre General Hospital | |
| Wilkes-Barre, Pennsylvania, United States, 18764 | |
| York Hospital | |
| York, Pennsylvania, United States, 17315 | |
| United States, Rhode Island | |
| Roger Williams Medical Center/BUSM | |
| Providence, Rhode Island, United States, 02908-4735 | |
| United States, South Carolina | |
| CCOP - Greenville | |
| Greenville, South Carolina, United States, 29615 | |
| CCOP - Upstate Carolina | |
| Spartanburg, South Carolina, United States, 29303 | |
| United States, South Dakota | |
| Rapid City Regional Hospital | |
| Rapid City, South Dakota, United States, 57709 | |
| CCOP - Sioux Community Cancer Consortium | |
| Sioux Falls, South Dakota, United States, 57104 | |
| United States, Tennessee | |
| Jackson-Madison County General Hospital | |
| Jackson, Tennessee, United States, 38301 | |
| University of Tennessee, Memphis Cancer Center | |
| Memphis, Tennessee, United States, 38103 | |
| Vanderbilt-Ingram Cancer Center | |
| Nashville, Tennessee, United States, 37232-6838 | |
| United States, Texas | |
| Harrington Cancer Center | |
| Amarillo, Texas, United States, 79106 | |
| University of Texas Medical Branch | |
| Galveston, Texas, United States, 77555-0209 | |
| University of Texas - MD Anderson Cancer Center | |
| Houston, Texas, United States, 77030-4009 | |
| Wilford Hall - 59th Medical Wing | |
| Lackland Air Force Base, Texas, United States, 78236-5300 | |
| Joe Arrington Cancer Research and Treatment Center | |
| Lubbock, Texas, United States, 79410-1894 | |
| Bayshore Medical Center | |
| Pasadena, Texas, United States, 77504 | |
| United States, Utah | |
| Dixie Regional Medical Center | |
| Saint George, Utah, United States, 84770 | |
| Latter Day Saints Hospital | |
| Salt Lake City, Utah, United States, 84143 | |
| University of Utah Health Sciences Center | |
| Salt Lake City, Utah, United States, 84132 | |
| United States, Vermont | |
| Green Mountain Oncology Group | |
| Bennington, Vermont, United States, 05201 | |
| Vermont Cancer Center | |
| Burlington, Vermont, United States, 05401-3498 | |
| United States, Virginia | |
| Cancer Center at the University of Virginia | |
| Charlottesville, Virginia, United States, 22908 | |
| RMH Regional Cancer Center | |
| Harrisonburg, Virginia, United States, 22801 | |
| Naval Medical Center, Portsmouth | |
| Portsmouth, Virginia, United States, 23708-2197 | |
| Massey Cancer Center | |
| Richmond, Virginia, United States, 23298-0037 | |
| Bon-Secours - St. Mary's Hospital | |
| Richmond, Virginia, United States, 23226 | |
| United States, Washington | |
| Virginia Mason Medical Center | |
| Seattle, Washington, United States, 98111 | |
| Deaconess Medical Center | |
| Spokane, Washington, United States, 99210-0248 | |
| Yakima Valley Memorial Hospital | |
| Yakima, Washington, United States, 98902 | |
| United States, West Virginia | |
| Schiffler Cancer Center | |
| Wheeling, West Virginia, United States, 26003 | |
| United States, Wisconsin | |
| CCOP - Green Bay | |
| Green Bay, Wisconsin, United States, 54301 | |
| St. Vincent Hospital | |
| Green Bay, Wisconsin, United States, 54307-3508 | |
| Gundersen Lutheran Medical Foundation | |
| La Crosse, Wisconsin, United States, 54601 | |
| Southern Wisconsin Radiotherapy Center | |
| Madison, Wisconsin, United States, 53713 | |
| University of Wisconsin Comprehensive Cancer Center | |
| Madison, Wisconsin, United States, 53792-6164 | |
| Marshfield Clinic | |
| Marshfield, Wisconsin, United States, 54449 | |
| Community Memorial Hospital | |
| Menomonee Falls, Wisconsin, United States, 53051 | |
| Medical College of Wisconsin | |
| Milwaukee, Wisconsin, United States, 53226 | |
| St. Luke's Medical Center | |
| Milwaukee, Wisconsin, United States, 53215 | |
| Columbia Hospital | |
| Milwaukee, Wisconsin, United States, 53211 | |
| All Saints Cancer Center | |
| Racine, Wisconsin, United States, 53405 | |
| Waukesha Memorial Hospital | |
| Waukesha, Wisconsin, United States, 53188 | |
| Canada, Alberta | |
| Tom Baker Cancer Center - Calgary | |
| Calgary, Alberta, Canada, T2N 4N2 | |
| Cross Cancer Institute | |
| Edmonton, Alberta, Canada, T6G 1Z2 | |
| Canada, New Brunswick | |
| Saint John Regional Hospital | |
| Saint John, New Brunswick, Canada, E2L 4L2 | |
| Canada, Newfoundland and Labrador | |
| Newfoundland Cancer Treatment and Research Foundation | |
| St. Johns, Newfoundland and Labrador, Canada, A1B 3V6 | |
| Canada, Nova Scotia | |
| Nova Scotia Cancer Centre | |
| Halifax, Nova Scotia, Canada, B3H 1V7 | |
| Canada, Ontario | |
| Cancer Care Ontario-Hamilton Regional Cancer Centre | |
| Hamilton, Ontario, Canada, L8V 5C2 | |
| Kingston Regional Cancer Centre | |
| Kingston, Ontario, Canada, K7L 5P9 | |
| Cancer Care Ontario-London Regional Cancer Centre | |
| London, Ontario, Canada, N6A 4L6 | |
| Ottawa Regional Cancer Centre | |
| Ottawa, Ontario, Canada, K1H 1C4 | |
| Northeastern Ontario Regional Cancer Centre, Sudbury | |
| Sudbury, Ontario, Canada, P3E 5J1 | |
| Northwestern Ontario Regional Cancer Centre, Thunder Bay | |
| Thunder Bay, Ontario, Canada, P7A 7T1 | |
| Princess Margaret Hospital | |
| Toronto, Ontario, Canada, M5G 2M9 | |
| Toronto Sunnybrook Regional Cancer Centre | |
| Toronto, Ontario, Canada, M4N 3M5 | |
| Canada, Quebec | |
| CHUS-Hopital Fleurimont | |
| Fleurimont, Quebec, Canada, J1H 5N4 | |
| Centre Hospitalier de l'Universite de Montreal | |
| Montreal, Quebec, Canada, H2L-4M1 | |
| McGill University | |
| Montreal, Quebec, Canada, H2W 1S6 | |
| Centre Hospitalier Universitaire de Quebec | |
| Quebec City, Quebec, Canada, G1R 2J6 | |
| Canada, Saskatchewan | |
| Allan Blair Cancer Centre | |
| Regina, Saskatchewan, Canada, S4T 7T1 | |
| Saskatoon Cancer Centre | |
| Saskatoon, Saskatchewan, Canada, S7N 4H4 | |
| Study Chair: | William F. Hartsell, MD | Lutheran General Hospital |
| Study Chair: | Ivy A. Petersen, MD | Mayo Clinic |
More Information
Additional Information:
Publications:
| ClinicalTrials.gov Identifier: | NCT00003162 History of Changes |
| Other Study ID Numbers: | CDR0000065957, RTOG-9714, NCCTG-R9714, NCI-P97-0124 |
| Study First Received: | November 1, 1999 |
| Last Updated: | July 29, 2009 |
| Health Authority: | United States: Federal Government |
Keywords provided by National Cancer Institute (NCI):
|
stage IV breast cancer recurrent breast cancer stage IV prostate cancer |
recurrent prostate cancer bone metastases pain |
Additional relevant MeSH terms:
|
Breast Neoplasms Neoplasm Metastasis Neoplasms Neoplasms, Second Primary Prostatic Neoplasms Neoplasms by Site Breast Diseases |
Skin Diseases Neoplastic Processes Pathologic Processes Genital Neoplasms, Male Urogenital Neoplasms Genital Diseases, Male Prostatic Diseases |
ClinicalTrials.gov processed this record on May 23, 2013