Determination of the Duration of Action of a Lidocaine and a Bupivacaine Digital Nerve Block in Human Volunteers

This study is currently recruiting participants.
Verified November 2012 by University of California, San Francisco
Sponsor:
Information provided by (Responsible Party):
University of California, San Francisco
ClinicalTrials.gov Identifier:
NCT01508832
First received: January 9, 2012
Last updated: November 16, 2012
Last verified: November 2012

January 9, 2012
November 16, 2012
January 2012
March 2013   (final data collection date for primary outcome measure)
Duration of an autonomic (sympathetic) nerve block as measured by the time to the return of blocked finger temperature to the immediate pre-block baseline. Duration of autonomic nerve block: return to baseline finger temperature [ Time Frame: Time to return of blocked finger temperature to the immediate pre-block baseline ] [ Designated as safety issue: No ]
Duration of an autonomic (sympathetic) nerve block as measured by the time to the return of blocked finger temperature to the immedidate pre-block baseline. Duration of autonomic nerve block: return to baseline finger temperature [ Designated as safety issue: No ]
Complete list of historical versions of study NCT01508832 on ClinicalTrials.gov Archive Site
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Determination of the Duration of Action of a Lidocaine and a Bupivacaine Digital Nerve Block in Human Volunteers
Not Provided

The duration of the autonomic (sympathetic) block will last longer than the sensory block. The duration of the increased perfusion index will last longer than either the sympathetic or sensory block.

Not Provided
Interventional
Phase 4
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Outcomes Assessor)
Onset and Duration of a Digital Nerve Block With 2 Local Anesthetics.
  • Drug: Lidocaine
    Lidocaine 1%, 2cc Digital Nerve Block x 1 dose
  • Drug: Bupivacaine
    Bupivacaine 0.25%, 2cc x 1
  • Active Comparator: Lidocaine Digital Nerve Block
    Lidocaine Digital Nerve Block
    Intervention: Drug: Lidocaine
  • Active Comparator: Bupivacaine Digital Nerve Block
    Bupivacaine Digital Nerve Block
    Intervention: Drug: Bupivacaine
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
15
June 2013
March 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Non-smokers

Exclusion Criteria:

  • History of allergic response to local anesthetics
  • BMI >25
  • Pregnant of nursing
  • Current smokers or past smokers of > 1 pack year history
  • Neurological deficit and/or injury in the upper extremities
  • Current respiratory infection
  • Per investigator judgement, would not be suitable for study
Both
18 Years and older
Yes
Contact: Ronald D Miller, MD 415 476-9034 millerr@anesthesia.ucsf.edu
Contact: Theresa A Ward, BSN, RN 415 514-0685 wardt@anesthesia.ucsf.edu
United States
 
NCT01508832
11-06121
Yes
University of California, San Francisco
University of California, San Francisco
Not Provided
Principal Investigator: Ronald Miller, MD University of California, San Francisco
University of California, San Francisco
November 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP