Prospective Trial to Reduce Morbidity and Mortality After Lung Surgery in Patients With Reduced Pulmonary Capacity

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2007 by University of Ulm.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
University of Heidelberg
Information provided by:
University of Ulm
ClinicalTrials.gov Identifier:
NCT00530491
First received: September 13, 2007
Last updated: February 1, 2008
Last verified: September 2007

September 13, 2007
February 1, 2008
September 2007
September 2008   (final data collection date for primary outcome measure)
pulmonary complications (air leak, atelectasis, pneumonia); lung function on pod 7; overall mortality [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]
pulmonary complications (air leak, atelectasis, pneumonia); lung function on pod 7; overall mortality [ Time Frame: 1 year ]
Complete list of historical versions of study NCT00530491 on ClinicalTrials.gov Archive Site
duration of ICU treatment [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]
duration of ICU treatment [ Time Frame: 1 year ]
Not Provided
Not Provided
 
Prospective Trial to Reduce Morbidity and Mortality After Lung Surgery in Patients With Reduced Pulmonary Capacity
Prospective Randomized Controlled Trial to Reduce Morbidity and Mortality After Lung Surgery in Patients With FEV1 < 70% of Expected Value or < 1.5L

A fast track recovery program (thoracic epidural anesthesia, carbohydrate drink preoperative, early removal of chest tubes) is evaluated compared to conventional perioperative treatment (patient controlled analgesia, no carbohydrate drink preoperative) in patients with FEV1 < 70% of expected value or < 1.5L who undergo resections of the lung.

Not Provided
Interventional
Not Provided
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Respiration Disorders
Procedure: Fast track lung surgery
fast track lung surgery: carbohydrate drink preoperatively, PCEA, early removal of chest tube conventional: no carbohydrate drink preoperatively, ICB+PCA, removal of chest tube depending upon chest x-ray
  • Active Comparator: 1
    conventional perioperative management for lung surgery
    Intervention: Procedure: Fast track lung surgery
  • Experimental: 2
    fast track management for lung surgery
    Intervention: Procedure: Fast track lung surgery
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
90
October 2008
September 2008   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • resection of the lung
  • FEV1 <70% of expected value or below 1.5L
  • 18-80y
  • given written informed consent

Exclusion Criteria:

  • contraindication for epidural anesthesia
  • prio ipsilateral thoracotomy
  • chemotherapy <6 weeks prior to study enter
  • existing pneumonia (fever, elevated WCC, elevated CRP)
Both
18 Years to 80 Years
No
Contact: Bernd M Muehling, M.D. +49-731-500 ext 54044 bernd.muehling@uniklinik-ulm.de
Contact: Karl-Heinz Orend, M.D., Ph.D. +49-731-500 ext 54005 karl-heinz.orend@uniklinik-ulm.de
Germany
 
NCT00530491
BM 140/07
No
Bernd Muehling, M.D., Dep. of Thoracic and Vascular Surgery, University of Ulm , Germany
University of Ulm
University of Heidelberg
Study Chair: Bernd M Muehling, M.D.
University of Ulm
September 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP