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Urinary Concentration and Diluting Ability in Patients With Chronic Renal Disease and/ or Hypertension

This study has been completed.
Sponsor:
Information provided by:
Regional Hospital Holstebro
ClinicalTrials.gov Identifier:
NCT00313430
First received: April 11, 2006
Last updated: February 28, 2010
Last verified: February 2010
History of Changes

April 11, 2006
February 28, 2010
May 2004
March 2008   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00313430 on ClinicalTrials.gov Archive Site
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Urinary Concentration and Diluting Ability in Patients With Chronic Renal Disease and/ or Hypertension
Urinary Concentration and Diluting Ability in Patients With Chronic Renal Disease or Hypertension

The investigators want to test the hypothesis that patients with chronic renal disease have a poorer ability to preserve water after being thirsty and a poorer ability to excrete water after a load of fluid. They presume that these abilities become poorer when renal insufficiency progresses. The investigators further hypothesize that patients with hypertension also have a decreased ability to concentrate and dilute urine.
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Observational
Observational Model: Case Control
Time Perspective: Cross-Sectional
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Non-Probability Sample

Healthy participants were recruited by advertisements in public and private institutions Patients with primary hypertension or chronic renal failure were recruited from the Out-patients' Clinic, Department of Medicine, Section of Nephrology, Holstebro Hospital
  • Renal Insufficiency, Chronic
  • Hypertension
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Pedersen EB, Thomsen IM, Lauridsen TG. Abnormal function of the vasopressin-cyclic-AMP-aquaporin2 axis during urine concentrating and diluting in patients with reduced renal function. A case control study. BMC Nephrol. 2010 Oct 5;11:26.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
50
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March 2008   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients with chronic renal insufficiency, aged between 18 and 65, both men and women
  • Creatinine clearance between 30-59 ml/min
  • Patients with hypertension, aged between 18 and 65, both men and women; hypertension is defined as a mean arterial blood pressure in the daytime that is more than 140/90 mm Hg.
  • Healthy volunteers, aged between 18 and 65, both men and women

Exclusion Criteria:

  • Clinical signs or history of disease in the heart, lungs, liver, brain, and endocrine organs
  • Cancer
  • Alcohol abuse
  • Medicine abuse
  • Pregnancy
Both
18 Years to 65 Years
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Contact information is only displayed when the study is recruiting subjects
Denmark
 
NCT00313430
MED. RES.HOS 2004 03/IT
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Holstebro Hospital, Erling Bjerregaard Pedersen
Regional Hospital Holstebro
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Study Chair: Erling B Pedersen, Professor Holstebro, Holstebro, Denmark
Regional Hospital Holstebro
February 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP