Oral Diindolylmethane (DIM) for the Treatment of Cervical Dysplasia

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2005 by New York Downtown Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
New York Downtown Hospital
ClinicalTrials.gov Identifier:
NCT00212381
First received: September 13, 2005
Last updated: NA
Last verified: September 2005
History: No changes posted

September 13, 2005
September 13, 2005
September 2000
Not Provided
To determine if oral DIM is effective in promoting the regression of CIN in women
Same as current
No Changes Posted
  • To correlate the response to DIM with HPV colonization
  • To assess for any adverse effects of oral DIM in women
Same as current
Not Provided
Not Provided
 
Oral Diindolylmethane (DIM) for the Treatment of Cervical Dysplasia
Diindolylmethane (DIM) Dietary Supplementation: A Nonsurgical Treatment for Cervical Intraepithelial Neoplasia (CIN)

To determine if the use of oral Diindolylmethante (DIM), a marketed cruciferous vegetable based dietary supplement (Bioresponse-DIM), is associated with the regression of cervical dysplasia in otherwise healthy women.

To determine if the use of oral Diindolylmethane (DIM), a marketed cruciferous vegetable based dietary supplement (BioResponse-DIM®), is associated with the regression of cervical dysplasia in otherwise healthy women. Additionally, the study aims to see how the use of the BioResponse-DIM supplement correlates with cervical HPV colonization, and to asses the tolerability of daily DIM supplementation

Interventional
Phase 3
Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Cervical Dysplasia
Drug: diindolylmethane (DIM)
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
62
August 2005
Not Provided

Inclusion Criteria:

  • Non pregnant women greater than or equal to 18 years of age able to consent
  • CIN II or III confirmed by histology
  • Karnofsky performance status >= 80
  • No prior treatment for dysplasia in the past 4 months

Exclusion Criteria:

  • Incompletely visible lesion
  • Diethylstilbestrol (DES) exposure
  • HIV seropositive
Female
18 Years to 80 Years
Yes
Contact: Roopa R Chakkappan, M.P.H 212-312-5268 roopa.chakkappan@downtownhospital.org
United States
 
NCT00212381
9218
Not Provided
Not Provided
New York Downtown Hospital
Not Provided
Study Director: Giuseppe Del Priore, M.D., M.P.H. NY Downtown Hospital
Principal Investigator: Alan Arslan, M.D. NYU School of Medicine
New York Downtown Hospital
September 2005

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP