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Depressed Cardiac Autonomic Modulation in Patients With Chronic Kidney Disease Diagnosed by Spectral Analysis (HRV)

This study has been completed.
Sponsor:
Information provided by:
Core Educational Research and Treatment in Nephrology
ClinicalTrials.gov Identifier:
NCT01376635
First received: June 2, 2011
Last updated: June 17, 2011
Last verified: May 2008
History of Changes
  Purpose

Background/Aims: To evaluate the sympathovagal balance in patients with chronic kidney disease (CKD) on conservative treatment. Methods: In a cross-sectional study, patients with CKD stages 3, 4 and 5 not yet on dialysis (CKD group) and age-matched healthy subjects (CON group) underwent continuous heart rate recording during two twenty-minute periods in the supine position (pre-inclined), followed by passive postural inclination at 70° (inclined period). Power spectral analysis of the heart rate variability was used to assess the normalized low frequency (LFnu), indicative of sympathetic activity, and the normalized high frequency (HFnu), indicative of parasympathetic activity. The LFnu/HFnu ratio represented sympathovagal balance.


Condition
Chronic Kidney Disease

Study Type: Observational
Study Design: Observational Model: Case-Crossover
Official Title: Depressed Cardiac Autonomic Modulation in Patients With Chronic Kidney Disease Diagnosed by Spectral Analysis of Heart Rate Variability Upon Postural Stress

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Core Educational Research and Treatment in Nephrology:

Enrollment: 46
Study Start Date: May 2008
Study Completion Date: May 2009
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   44 Years to 69 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

patients with CKD stages 3, 4 and 5 not yet on dialysis (CKD group) and age-matched healthy subjects (CON group)

Criteria

Inclusion Criteria:

  • We evaluated 32 individuals (18 men and 14 women) with CKD at stages 3, 4 or 5 who were not yet on dialysis

Exclusion Criteria:

  • Patients with severe cardiac disease, cancer, diabetes, collagen and demyelinating diseases, left ventricular systolic dysfunction, or a history of stroke were excluded
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01376635

Sponsors and Collaborators
Core Educational Research and Treatment in Nephrology
Investigators
Principal Investigator: Oliveira A Carlos, MD Core Educational Research and Treatment in Nephrology
  More Information

No publications provided

Responsible Party: Carlos Alberto de Oliveira, Core Educational Research and Treatment in Nephrology
ClinicalTrials.gov Identifier: NCT01376635     History of Changes
Other Study ID Numbers: CoreEdRTNephrology
Study First Received: June 2, 2011
Last Updated: June 17, 2011
Health Authority: Brazil: Ethics Committee

Keywords provided by Core Educational Research and Treatment in Nephrology:
Chronic Kidney Disease
Autonomic Dysfunction

Additional relevant MeSH terms:
Kidney Diseases
Renal Insufficiency, Chronic
Kidney Failure, Chronic
Urologic Diseases
Renal Insufficiency

ClinicalTrials.gov processed this record on June 13, 2013