Aerobic Exercise to Improve Executive Language Function In Older Adults

This study has been completed.
Information provided by (Responsible Party):
Department of Veterans Affairs Identifier:
First received: September 15, 2009
Last updated: January 27, 2012
Last verified: January 2012

The purpose of this study is to see if exercise can improve brain function in older adults

Condition Intervention
Behavioral: Aerobic group
Behavioral: Strength training

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Aerobic Exercise to Improve Executive Language Function in Older Adults

Resource links provided by NLM:

Further study details as provided by Department of Veterans Affairs:

Primary Outcome Measures:
  • Executive Language Functions [ Time Frame: pre and post separated by 12 weeks ] [ Designated as safety issue: No ]

Enrollment: 50
Study Start Date: September 2010
Study Completion Date: January 2012
Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
12 weeks of aerobic exercise 3 times a week
Behavioral: Aerobic group
12 weeks of aerobic exercise 3 times a week
Active Comparator: 2
12 weeks of strength training 3 times a week
Behavioral: Strength training
12 weeks of strength training 3 times a week

Detailed Description:

Recently, considerable attention has been devoted to examining the beneficial relationship between cognition and aerobic exercise in older adults. Specifically, the effects are thought to involve higher order cognitive processes, such as working memory, switching between tasks, and inhibiting irrelevant information, all of which are thought to be sub- served, in part, by the frontal lobes (Colcombe et al., 2006). Importantly, these areas also are most susceptible to age-related decline (Raz, 2000) and are essential resources for language production (Kemper & Sumner, 2001; Murray & Lenz, 2001). However, despite promising cognitive improvement, changes in frontally-mediated executive language functions have been widely ignored. This is unfortunate considering impaired word retrieval compromises communicative effectiveness, leading to frustration, depression, and withdrawal. Perhaps more importantly, communication ineffectiveness, particularly in the elderly, leads to difficulties interacting with health care professionals leading to further health care burdens. Since cognition, and specifically word retrieval difficulties, usually remain untreated, it is important to find treatment strategies for minimizing these deficits. Therefore, the short-term goal and the purpose of this proposal is to examine the potential of aerobic exercise to improve executive language function in older adults.


Ages Eligible for Study:   55 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Consent of participants' primary health care physicians to participate in the aerobic exercise.
  • Patients must not have participated in any consistent exercise program or experimental study for at least 3 months prior to enrollment.
  • They must be capable of providing informed consent and complying with the trial procedures.

Exclusion Criteria:

  • Demented as defined by the Modified Mini Mental Status Exam.
  • Unalterable travel schedules.
  • Site accessibility constraints.
  Contacts and Locations
Please refer to this study by its identifier: NCT00979069

United States, Florida
North Florida/South Georgia Veterans Health System
Gainesville, Florida, United States, 32608
Sponsors and Collaborators
Principal Investigator: Joe R Nocera, PhD North Florida/South Georgia Veterans Health System
  More Information

No publications provided

Responsible Party: Department of Veterans Affairs Identifier: NCT00979069     History of Changes
Other Study ID Numbers: E6860M
Study First Received: September 15, 2009
Last Updated: January 27, 2012
Health Authority: United States: Federal Government processed this record on April 16, 2014