Evaluation of Different Disease Control Indices in Children With Asthma and Rhinitis
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Purpose
In this study will be consecutive enrolled children with asthma (classified according to GINA guidelines) and rhinitis (classified by ARIA guidelines); the investigators will research clinical personal and parental history regarding allergic diseases, exposition to passive smoking and interpretate hematochemical parameters markers of atopy. Skin Prick Tests will be performed. In this study the investigators will evaluate lung function parameters (spirometry with bronchial reversibility test and exercise induced bronchoconstriction, oscillometry, respiratory plethysmography, etc.), airway inflammatory indices such as exhaled nitric oxide at different flows, exhaled and nasal temperature, nasal cytology.
The aim of the study will be to evaluate possible correlation between these different parameters and clinical status of the patients.
| Condition | Intervention |
|---|---|
|
Asthma Rhinitis |
Other: regular treatment |
| Study Type: | Observational |
| Study Design: | Observational Model: Case-Only Time Perspective: Cross-Sectional |
| Official Title: | Evaluation of Different Disease Control Indices in Children With Asthma and Rhinitis |
| Estimated Enrollment: | 1000 |
| Study Start Date: | July 2009 |
| Groups/Cohorts | Assigned Interventions |
|---|---|
| asthma and rhinitis control |
Other: regular treatment
regular treatment
Other Name: asthma treatment
|
Detailed Description:
Each patients will be evaluated by spirometry and then he will undergo exercise challenge in order to evaluate exercise-induced bronchoconstriction as a marker of asthma control. The test of the challenge will be correlate with childhood Asthma control test score,levels of control (GINA classification)and the different markers of airway inflammation and atopy.
Eligibility| Ages Eligible for Study: | 5 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
children with asthma and/or rhinitis visited at the outpatients clinic at the University of Verona will be invited to participate to the study
Inclusion Criteria:
- patient with asthma and rhinitis
Exclusion Criteria:
- age <5 years
- chronic respiratory diseases
Contacts and Locations| Contact: Attilio Boner, MD | --390458124615 | attilio.boner@univr.it |
| Italy | |
| Pediatric department University of Verona | Recruiting |
| Verona, Italy, 37134 | |
| Contact: Attilio Boner, MD --390458124615 attilio.boner@univr.it | |
| Principal Investigator: Attilio Boner, MD | |
| Sub-Investigator: Iolanda Chinellato, MD | |
| Principal Investigator: | Attilio Boner, MD | Universita di Verona |
More Information
No publications provided by Universita di Verona
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
| Responsible Party: | Boner Attilio, full professor, Universita di Verona |
| ClinicalTrials.gov Identifier: | NCT00952835 History of Changes |
| Other Study ID Numbers: | AOV-1716 |
| Study First Received: | August 3, 2009 |
| Last Updated: | May 24, 2012 |
| Health Authority: | Italy: National Bioethics Committee |
Keywords provided by Universita di Verona:
|
Asthma rhinitis EIB |
Exhaled Nitric oxide lung function vitamin d |
Additional relevant MeSH terms:
|
Asthma Rhinitis Bronchial Diseases Respiratory Tract Diseases Lung Diseases, Obstructive Lung Diseases Respiratory Hypersensitivity |
Hypersensitivity, Immediate Hypersensitivity Immune System Diseases Nose Diseases Respiratory Tract Infections Otorhinolaryngologic Diseases |
ClinicalTrials.gov processed this record on May 23, 2013