Protein Expression in Tumor Tissue Samples From Patients With Cancer of the Oropharynx

• Development of biomarkers for early detection or recurrence surveillance [ Time Frame: after 7 months of tissue collection ] [ Designated as safety issue: No ]
  
• Identification of therapeutic targets and individualization of treatment based on the biology of squamous cell carcinoma of the oropharynx [ Time Frame: after 7months of tissue collection ] [ Designated as safety issue: No ]
  

Genetic: gene expression analysis
profiles of HPV(+) and (-) HNSCCs
Other Name: gene expression analysis
Genetic: microarray analysis
microarray analysis
Other Name: SAM - significance Analysis of microarrays
Genetic: protein expression analysis
protein expression analysis
Other Name: protein expression analysis
Other: immunohistochemistry staining method
immunohistochemistry staining method
Other Name: immunohistochemistry staining method
Other: laboratory biomarker analysis
laboratory biomarker analysis
Other Name: laboratory biomarker analysis

OBJECTIVES:

• To investigate if some of the differences in gene expression are also reflected at the protein level.
• To determine whether differences in gene expression that are also reflected at the protein level can be used to develop markers for early detection and disease surveillance.
• To identify targets for therapy.

OUTLINE: Archived tumor tissue samples are analyzed for expression of standard immunohistological markers (e.g., p16, p53, and Ki-67) as well as expression of genes identified in a previous gene expression study. Protein expression data are tested for clinical and demographic correlates and compared with gene expression data.