Vascular Reactivity in Metabolic Syndrome and Diabetic Patients Using Diffuse Optical Spectroscopy
This is a pilot study to determine whether changes in tissue oxygenation, oxygen metabolism, and indicators of tissue damage can non-invasively be quantified using DOS in patients with Metabolic Syndrome, patients with both Type I DM, Type II DM, and in non-diseased subjects.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Diffuse Optical Spectroscopy Measure Microvascular Changes in Metabolic Syndrome and Diabetes Mellitus in Order to Assess Cardiovascular Disease Risk.|
- To monitor microvascular changes in patients with Metabolic Syndrome and with DM to assess their disease progression and cardiovascular risks. [ Time Frame: 4 weeks ] [ Designated as safety issue: No ]
|Study Start Date:||November 2008|
|Study Completion Date:||November 2013|
|Primary Completion Date:||November 2013 (Final data collection date for primary outcome measure)|
Device: Diffuse Optical Spectroscopy
The researchers want to use DOS as a means to monitor changes in the microvasculature of patients with Metabolic Syndrome and DM, and patients with DPN, versus non-diseased and predisposed subjects by evaluating the changes in oxygen metabolism. This will be done by measuring the changes in the concentration and oxygen saturation of hemoglobin in the microvasculature under stress, for example, during exercise and in response to changes in breathing habits. The sensitivity of DOS to tissue hemodynamics provides an impressive arena of useful clinical applications..
Please refer to this study by its ClinicalTrials.gov identifier: NCT00793481
|United States, California|
|Beckman Laser Institute Medical clinic|
|Irvine, California, United States, 92612|
|Principal Investigator:||Ping H Wang, M.D.||Joslin Diabetes Center,UCI|