Validation of Brief Objective Neurobehavioral Detectors (BOND) in Mild TBI
The Veterans Health Administration (VHA) has stated the need for a brief screening instrument that can assist with the triage of the enormous number of returning OEF/OIF veterans with concussion. The investigators combined selected neurological and brief cognitive tests to develop an instrument called, "Brief Objective Neurobehavioral Detectors" (BOND). The BOND takes only 15-20 minutes to administer with immediate results. In a previous study, the BOND was able to predict periventricular white matter disease (PWMD) visible on MRI scans with 91% sensitivity and 76% specificity. Thus, the BOND has shown sensitivity to, and specificity for, white matter abnormalities. Given that white matter abnormalities are the most common type of injury in mTBI, it is probable that the BOND could be sensitive to traumatic axonal injury (TAI) in TBI. Advanced neuroimaging measures, such as diffusion tensor imaging, will be used to help validate the BOND. If validated as a screening tool for OEF/OIF veterans with concussion, the BOND could reduce evaluation and associated waiting times and accelerate the initiation of treatment or case management. These benefits would be expected to increase veteran quality of life and satisfaction with care.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Validation of Brief Objective Neurobehavioral Detectors of Mild TBI|
- Total Score: Brief Objective Neurobehavioral Evaluation (BOND) [ Time Frame: At single evaluation visit ] [ Designated as safety issue: No ]
|Study Start Date:||May 2008|
|Estimated Study Completion Date:||June 2013|
|Estimated Primary Completion Date:||June 2013 (Final data collection date for primary outcome measure)|
Validation study of screening instrument.
As of November 2012, 75 of the 100 planned sample have been recruited and evaluated. Recruitment and enrollment is continuing.
|Contact: Lauren Roselli||(202) 745-8000 ext 7553||Chapman.Research@va.gov|
|Contact: Julie C Chapman||(202) 745-8000 ext email@example.com|
|United States, District of Columbia|
|VA Medical Center, DC||Recruiting|
|Washington, District of Columbia, United States, 20422|
|Contact: Lauren Roselli 202-745-8000 ext 7553 Chapman.Research@va.gov|
|Principal Investigator: Julie C. Chapman|
|Principal Investigator:||Julie C. Chapman||VA Medical Center, DC|