The Effect of Clopidogrel on Coated-Platelets in Patients Undergoing Cardiac Catheterization
This study will explore the effect of clopidogrel on coated-platelets in patients who are given a loading dose before diagnostic catheterization or percutaneous coronary intervention. We hypothesis that clopidogrel will reduce the percentage of platelets that are coated and therefore more hypercoagulable.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||The Effect of Clopidogrel on Coated-Platelets in Patients Undergoing Cardiac Catheterization|
- The Percentage of Coated Platelets After the Administration of Clopidogrel in Patients Undergoing Cardiac Catheterization and/or Angioplasty [ Time Frame: 24 hours after the administration of clopidotrel ] [ Designated as safety issue: No ]The percentage of platelets that are collagen coated after the administration of clopidogrel.
- The Percentage of Coated Platelets After Coronary Angiography and/or PCI [ Time Frame: 6 hrs after procedure ] [ Designated as safety issue: No ]The percentage of coated platelets 24 hours after coronary angiography and/or PCI
|Study Start Date:||March 2007|
|Study Completion Date:||September 2008|
|Primary Completion Date:||September 2008 (Final data collection date for primary outcome measure)|
Platelet activity will be determined by light transmission aggregometry at baseline, after a 300 mg dose of clopidogrel and after the catheterization and/or angioplasty procedure. The change in the percentage of platelets that are coated platelets will be determined.
|United States, Oklahoma|
|VA Medical Center, 1F187|
|Oklahoma City, Oklahoma, United States, 73104-5076|
|Principal Investigator:||Eliot Schechter, MD||University of Oklahoma|