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Effect of Weight Reduction on Inflammatory Markers and Genes Expression in Obese Individuals

This study has been completed.
Sponsor:
Information provided by:
Taichung Veterans General Hospital
ClinicalTrials.gov Identifier:
NCT00416156
First received: December 25, 2006
Last updated: December 26, 2006
Last verified: December 2006
History of Changes
  Purpose

To investigate whether weight reduction by life style modification for 12 weeks will improve circulating inflammatory markers, adipocytokines as well as gene expression of proinflammatory protein obtained from circulating monocytes from obese individuals.


Condition Intervention
Obesity
Inflammation
 Behavioral: Lifestyle modification

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Taichung Veterans General Hospital:

Primary Outcome Measures:
  • Inflammatory responses after weight reduction

Secondary Outcome Measures:
  • BMI
  • Circulating inflammatory markers
  • Adipocytokines
  • Gene Expression from mononuclear cells

Estimated Enrollment: 25
Study Start Date: May 2005
Estimated Study Completion Date: November 2005
  Eligibility

Ages Eligible for Study:   20 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Nondiabetes obese individuals with BMI greater than 27 kgs/m2

Exclusion Criteria:

  • Diabetes
  • Abnormal hepatic, renal and cardiac function
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00416156

Locations
Taiwan
Taichung Veterans General Hospital
Taichung, Taiwan
Sponsors and Collaborators
Taichung Veterans General Hospital
Investigators
Principal Investigator: Wayne H Sheu, MD, PhD Taichung Veterans General Hospital
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00416156     History of Changes
Other Study ID Numbers: TCVGH 05082
Study First Received: December 25, 2006
Last Updated: December 26, 2006
Health Authority: Taiwan: Department of Health

Keywords provided by Taichung Veterans General Hospital:
Obesity
Inflammation

Additional relevant MeSH terms:
Inflammation
Obesity
Pathologic Processes
Overnutrition
 Nutrition Disorders
Overweight
Body Weight
Signs and Symptoms

ClinicalTrials.gov processed this record on June 18, 2013