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Urinary Concentration and Diluting Ability in Patients With Chronic Renal Disease and/ or Hypertension

This study has been completed.
Sponsor:
Information provided by:
Regional Hospital Holstebro
ClinicalTrials.gov Identifier:
NCT00313430
First received: April 11, 2006
Last updated: February 28, 2010
Last verified: February 2010
History of Changes
  Purpose

The investigators want to test the hypothesis that patients with chronic renal disease have a poorer ability to preserve water after being thirsty and a poorer ability to excrete water after a load of fluid. They presume that these abilities become poorer when renal insufficiency progresses. The investigators further hypothesize that patients with hypertension also have a decreased ability to concentrate and dilute urine.


Condition
Renal Insufficiency, Chronic
Hypertension

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Urinary Concentration and Diluting Ability in Patients With Chronic Renal Disease or Hypertension

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Regional Hospital Holstebro:

Enrollment: 50
Study Start Date: May 2004
Primary Completion Date: March 2008 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Sampling Method:   Non-Probability Sample
Study Population

Healthy participants were recruited by advertisements in public and private institutions Patients with primary hypertension or chronic renal failure were recruited from the Out-patients' Clinic, Department of Medicine, Section of Nephrology, Holstebro Hospital

Criteria

Inclusion Criteria:

  • Patients with chronic renal insufficiency, aged between 18 and 65, both men and women
  • Creatinine clearance between 30-59 ml/min
  • Patients with hypertension, aged between 18 and 65, both men and women; hypertension is defined as a mean arterial blood pressure in the daytime that is more than 140/90 mm Hg.
  • Healthy volunteers, aged between 18 and 65, both men and women

Exclusion Criteria:

  • Clinical signs or history of disease in the heart, lungs, liver, brain, and endocrine organs
  • Cancer
  • Alcohol abuse
  • Medicine abuse
  • Pregnancy
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00313430

Locations
Denmark
Department of Medicine, Holstebro Hospital
Holstebro, Ringkjoebing, Denmark, 7500
Sponsors and Collaborators
Regional Hospital Holstebro
Investigators
Study Chair: Erling B Pedersen, Professor Holstebro, Holstebro, Denmark
  More Information

No publications provided by Regional Hospital Holstebro

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Responsible Party: Holstebro Hospital, Erling Bjerregaard Pedersen
ClinicalTrials.gov Identifier: NCT00313430     History of Changes
Other Study ID Numbers: MED. RES.HOS 2004 03/IT
Study First Received: April 11, 2006
Last Updated: February 28, 2010
Health Authority: Denmark: Ethics Committee

Keywords provided by Regional Hospital Holstebro:
Urine concentration ability
chronic renal insufficiency
hypertension
aquaporin2
 Patients with chronic renal insufficiency
Patients with hypertension
Healthy volunteers

Additional relevant MeSH terms:
Hypertension
Kidney Diseases
Kidney Failure, Chronic
Renal Insufficiency, Chronic
 Renal Insufficiency
Vascular Diseases
Cardiovascular Diseases
Urologic Diseases

ClinicalTrials.gov processed this record on May 22, 2013