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Hereditary Paraganglioma: Evaluation of Screening Methods to Detect Tumors in SDH Positive Carriers

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2005 by University Hospital, Angers.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
Assistance Publique - Hôpitaux de Paris
Information provided by:
University Hospital, Angers
ClinicalTrials.gov Identifier:
NCT00188019
First received: September 12, 2005
Last updated: NA
Last verified: September 2005
History: No changes posted
  Purpose

Hereditary paraganglioma -due to SDH (SDHD, SDHB, SDHC) germline mutations- causes paragangliomas and pheochromocytomas. Presymptomatic genetic testing should be offered to all first-degree relatives if an SDH mutation is detected in an index case with paraganglioma or pheochromocytoma. The main objective of our national clinical research project is to test different screening methods to detect presymptomatic tumors in order to establish guidelines for the work-up and the follow-up of SDH mutation carriers.


Condition Intervention
Paraganglioma
Pheochromocytoma
 Procedure: diagnosis methods

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
Official Title: Evaluation Des méthodes De dépistage Du Paragangliome héréditaire Chez Les Sujets prédisposés génétiquement

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University Hospital, Angers:

  Eligibility

Ages Eligible for Study:   6 Years and older
Genders Eligible for Study:   Both
Criteria

Inclusion Criteria: identification of an SDH (SDHD, SDHD, SDHC) germline mutation

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00188019

Contacts
Contact: Anne-Paule Gimenez-Roqueplo, MD, PhD 33 1 56 09 38 81 anne-paule.gimenez@hop.egp.ap-hop-paris.fr

Locations
France
Européen Georges Pompidou Hospital Recruiting
Paris, France, 75015
Contact: Anne-Paule Gimenez-Roqueplo, MD, PhD     33 1 56 09 38 78 ext 38 81     anne-paule.gimenez@hop.egp.ap-hop-paris.fr    
Principal Investigator: Anne-Paule Gimenez-Roqueplo, MD, PhD            
Sponsors and Collaborators
University Hospital, Angers
Assistance Publique - Hôpitaux de Paris
Investigators
Principal Investigator: Vincent Rohmer, MD University Angers Hospital
Principal Investigator: Anne-Paule Gimenez-Roqueplo, MD, PhD Paris-Descartes University, Européen Georges Pompidou Hospital, Assistance Publique des Hôpitaux de Paris
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00188019     History of Changes
Other Study ID Numbers: PHRC 04-01
Study First Received: September 12, 2005
Last Updated: September 12, 2005
Health Authority: France: Ministry of Health

Additional relevant MeSH terms:
Paraganglioma
Pheochromocytoma
Neuroendocrine Tumors
Neuroectodermal Tumors
 Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms
Neoplasms, Nerve Tissue

ClinicalTrials.gov processed this record on May 22, 2013